Evaluation of some new heterocycles bearing 2‐oxoquinolyl moiety as immunomodulator against highly pathogenic avian influenza virus (H5N8),Journal of Heterocyclic Chemistry

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Evaluation of some new heterocycles bearing 2‐oxoquinolyl moiety as immunomodulator against highly pathogenic avian influenza virus (H5N8)
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2021-01-26 , DOI: 10.1002/jhet.4233
Eman A. E. El‐Helw ₁ , Alaa R. I. Morsy ₂ , Ahmed I. Hashem ₁

Affiliation

The hydrazide obtained from furan‐2(3H)‐one integrated with a quinolin‐2(1H)‐one core reported previously by our research group was utilized as a building block synthon to obtain some pyrrolone, pyridazinone, oxadiazole, and triazole derivatives through treating with some carbon electrophilic reagents, for example, chloroacetyl chloride, benzoyl chloride, acetic anhydride, carbon disulfide, 3,4‐dimethoxybenzaldehyde, and 2‐oxoquinolin‐3‐carbaldehyde to achieve the target heterocycles. The newly synthesized compounds were evaluated as immunomodulator against highly pathogenic avian influenza virus (H₅N₈). The compounds 1, 11, and 17 displayed the highest potency (100% protection).

中文翻译：

评估一些带有2-氧代喹啉基部分作为针对高致病性禽流感病毒（H5N8）的免疫调节剂的杂环

我们研究小组先前报告的从呋喃-2（3 H）-与喹啉-2（1 H）-一核集成的酰肼用作构建基合成子，以获得一些吡咯烷酮，哒嗪酮，恶二唑和三唑通过使用一些碳亲电试剂（例如，氯乙酰氯，苯甲酰氯，乙酸酐，二硫化碳，3,4-二甲氧基苯甲醛和2-氧代喹啉-3-碳醛）处理来获得目标杂环。评价了新合成的化合物作为针对高致病性禽流感病毒（H ₅ N ₈）的免疫调节剂。化合物1，11，和17 显示出最高的效能（100％保护）。

更新日期：2021-04-02

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