The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.

严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 大流行继续扰乱个人生活、全球医疗保健系统和经济。因此，迫切需要一种预防病毒感染、传播和疾病的疫苗。在这里，我们提出了一种基于双组分蛋白质的纳米颗粒疫苗，它显示了 SARS-CoV-2 刺突蛋白的多个副本。免疫研究表明，该疫苗可在小鼠、兔子和食蟹猴中诱导有效的中和抗体反应。疫苗诱导的免疫力可以保护猕猴免受高剂量的攻击，从而大大减少上呼吸道和下呼吸道中的病毒感染和复制。这些纳米粒子是遏制 SARS-CoV-2 大流行的有前途的候选疫苗。