OBJECTIVES Recent studies have revealed that circular RNA (circRNA) plays a pivotal role in cancer development. The study aimed to investigate the role of circ_0081146 in gastric cancer (GC). RESULTS Circ_0081146 was upregulated in GC tissues and cells. Patients with high expression of circ_0081146 had a significantly reduced 5-year overall survival rate. Circ_0081146 knockdown restrained the growth, migration and invasion of GC cells in vitro as well as tumorigenesis in vivo. Circ_0081146 targeted miR-144 and HMGB1 was targeted by miR-144. Circ_0081146 was negatively correlated with miR-144 expression, while positively correlated with HMGB1 expression in GC tissues. Moreover, the inhibitory effect of circ_0081146 knockdown on the progression of GC cells were reversed by silencing miR-144 or HMGB1 overexpression. Mechanically, circ_0081146 increased HMGB1 expression by targeting miR-144. CONCLUSION Circ_0081146 functions as an oncogene in GC to promote cell growth, migration and invasion via modulating the miR-144/HMGB1 axis.

中文翻译：

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环状RNA 0081146通过海绵miR-144和上调HMGB1促进胃癌的进展

目标 最近的研究表明，环状 RNA (circRNA) 在癌症发展中起着关键作用。该研究旨在研究 circ_0081146 在胃癌 (GC) 中的作用。结果 Circ_0081146 在 GC 组织和细胞中上调。circ_0081146高表达的患者5年总生存率显着降低。Circ_0081146 敲低抑制了体外 GC 细胞的生长、迁移和侵袭以及体内肿瘤的发生。Circ_0081146 靶向 miR-144，HMGB1 被 miR-144 靶向。Circ_0081146 与 miR-144 的表达呈负相关，而与 GC 组织中 HMGB1 的表达呈正相关。此外，通过沉默 miR-144 或 HMGB1 过表达，可以逆转 circ_0081146 敲低对 GC 细胞进展的抑制作用。机械地，circ_0081146 通过靶向 miR-144 增加 HMGB1 表达。结论 Circ_0081146 作为胃癌的癌基因通过调节 miR-144/HMGB1 轴促进细胞生长、迁移和侵袭。