Our research group studied the biological regulatory mechanisms of the corpora lutea (CL), paying particular attention to the pseudopregnant rabbit model, which has the advantage that the relative luteal age following ovulation is induced by the gonadotrophin-releasing hormone (GnRH). CL are temporary endocrine structures that secrete progesterone, which is essential for maintaining a healthy pregnancy. It is now clear that, besides the classical regulatory mechanism exerted by prostaglandin E2 (luteotropic) and prostaglandin F2α (luteolytic), a considerable number of other effectors assist in the regulation of CL. The aim of this paper is to summarize our current knowledge of the multifactorial mechanisms regulating CL lifespan in rabbits. Given the essential role of CL in reproductive success, a deeper understanding of the regulatory mechanisms will provide us with valuable insights on various reproductive issues that hinder fertility in this and other mammalian species, allowing to overcome the challenges for new and more efficient breeding strategies.

中文翻译：

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关于黄体寿命的多因素调节的最新知识：兔子模型

我们的研究小组研究了黄体（CL）的生物调节机制，特别注意假孕兔模型，该模型的优势在于，促性腺激素释放激素（GnRH）可诱导排卵后相对黄体年龄。CL是分泌孕激素的临时内分泌结构，这对于维持健康的怀孕至关重要。现在清楚的是，除了前列腺素E2（促溶的）和前列腺素F2α（溶解的）发挥的经典调节机制外，大量其他效应子也有助于CL的调节。本文的目的是总结我们目前调控家兔CL寿命的多因素机制的知识。鉴于CL在生殖成功中的重要作用，