ABSTRACT

This study demonstrates the synthesis of a bioinspired surface exhibiting hydrophobic and antibacterial functionalities using a two-stage synthesis approach which involves soft lithography and initiated chemical vapour deposition (iCVD). Sandpapers, which are inexpensive and available with desired grit size, were used as the moulds in soft lithography to transfer the rough surface patterns to the PDMS replica surfaces. The antibacterial surface modification of the PDMS replicas was done through vapour-phase deposition of thin poly(diethylaminoethyl methacrylate-vinylbenzyl chloride) (P(DEAEMA-VBC)) films by iCVD method from the corresponding monomers. FTIR analysis of the as-deposited films showed a high retention of the chemical functionalities. The hydrophobicity and antibacterial performances of the flat and rough surfaces were examined as a function of surface roughness. The antibacterial activities were tested against gram-negative E. coli and gram-positive S. aureus. It was found that obtained replicas achieved up to a 7-log reduction in bacterial population and showed high hydrophobicity.

摘要

本研究展示了使用涉及软光刻和引发化学气相沉积 (iCVD) 的两阶段合成方法合成具有疏水和抗菌功能的仿生表面。砂纸价格低廉且具有所需的粒度，可用作软光刻中的模具，以将粗糙的表面图案转移到 PDMS 复制品表面。PDMS复制品的抗菌表面改性是通过iCVD方法从相应的单体气相沉积薄的聚（甲基丙烯酸二乙氨基乙酯-乙烯基苄基氯）（P（DEAEMA-VBC））薄膜来完成的。沉积膜的 FTIR 分析显示化学官能团的高度保留。作为表面粗糙度的函数，检查了平坦和粗糙表面的疏水性和抗菌性能。对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌的抗菌活性进行了测试。发现获得的复制品在细菌种群中实现了高达 7 个对数的减少，并显示出高疏水性。