Abstract

Increased blood lactic acid is likely to be involved in the incidence of sudden death syndrome (SDS) in broiler chicken. Guanidinoacetic acid (GAA) with direct or indirect influence on the cardiovascular system may provide, to some degree, protection against lactic acidemia in birds. A total number of 144 male broiler chicks (Ross 308) were used in a complete randomised block design to investigate the effects of dietary supplementation of GAA at 0.6, 1.2, 1.8, 2.4 and 3 g/kg on the physiological response of broiler chicks to an acute lactic acidosis in an 8-days experiment. Birds receiving 1.8 and 3 g/kg GAA exhibited lesser mortality percentage compared with the control birds and those received dietary GAA at 0.6 and 1.2 g/kg (p < .03). Dietary inclusion of 1.2 g/kg GAA to broiler chicks increased serum concentration of uric acid compared to the control birds and those received 2.4 g/kg (p < .02). The mean serum concentration of creatinine was greater in the birds receiving different GAA levels compared with the control birds (p < .0001). The serum concentration of nitric oxide decreased in the birds receiving 1.2 g/kg GAA by 21.05 and 15.57% compared with the control birds and those received 1.8 g/kg of GAA, respectively (p < .04). A lesser frequency for liver colour score 5 was observed in the birds fed on the diet with 0.6 g/k GAA (p < .0001). It was concluded that dietary administration of GAA deteriorates the adaptive physiological responses to an acute lactic acidosis in broiler chicken possibly through liver and kidney dysfunction.

• HIGHLIGHTS

• Dietary guanidinoacetic acid decreased mortality but showed an adverse effect on growth performance in chickens exposed to acute lactic acidosis.

• The adverse effects of guanidinoacetic acid may happen through liver and kidney dysfunction.

• No firm evidence was found to suggest a significant effect of extra nutritional guanidinoacetic acid on the incidence of sudden death syndrome in chicken.

摘要

血液乳酸增加可能与肉鸡猝死综合征（SDS）的发生有关。对心血管系统有直接或间接影响的胍基乙酸（GAA）可以在某种程度上为鸟类提供防止乳酸血症的保护。完全随机区组设计中使用了144只雄性肉鸡（Ross 308），以研究日粮中添加0.6、1.2、1.8、2.4和3 g / kg的GAA对肉鸡对鸡的生理反应的影响。在8天的实验中患有急性乳酸性酸中毒。接受1.8和3 g / kg GAA的禽类的死亡率要比对照鸟和接受饮食GAA的0.6和1.2 g / kg的死亡率要低（p <.03）。与对照鸡相比，肉鸡日粮中添加1.2 g / kg GAA会增加血清尿酸浓度，而对照组则为2.4 g / kg（p  <.02）。与对照组相比，接受不同GAA水平的鸡的肌酐平均血清浓度更高（p  <.0001）。与对照组和接受GAA的家禽相比，接受1.2 g / kg GAA的家禽的一氧化氮血清浓度分别降低21.05和15.57％（p  <.04）。在饲喂0.6 g / k GAA的家禽中，观察到的肝色评分5的频率较低（p <.0001）。结论是，饮食管理的GAA可能通过肉鸡的肝和肾功能障碍而恶化了对肉鸡急性乳酸性酸中毒的适应性生理反应。

• 强调

• 日粮胍基乙酸降低了死亡率，但对暴露于急性乳酸性酸中毒的鸡的生长性能显示了不利影响。

• 胍基乙酸的不良影响可能是由于肝肾功能不全引起的。

• 没有确定的证据表明额外的营养胍基乙酸对鸡猝死综合征的发生有显著作用。