ABSTRACT

Background

Stimulus selection is important to anomia treatment because similarity between trained and untrained words in the mental lexicon may influence treatment generalization. We focused on phonological similarity between trained and untrained words from a clinical trial of Phonomotor Treatment (PMT) that showed gains in confrontation naming accuracy of untrained words post-treatment. One way to capture the amount of similarity between the trained and untrained words is to consider the phonological network path distance between words. We posited that the distance between trained and untrained words in a phonological network could account for the improvement in confrontation naming accuracy post-treatment.

Aim

To define the phonological network distance between trained and untrained words that influences change in confrontation naming accuracy post-treatment.

Methods and procedures

We retrospectively analyzed data from 28 people with aphasia who received PMT as part of a clinical trial. Participants completed confrontation naming (baseline, post-treatment, and 3-months post-treatment) of words varying in phonological distance to the treatment stimuli. We used a phonological network to calculate the average shortest path length (ASPL), defined by the number of phoneme differences, between an untrained word and all trained words. We used mixed effects regression models to predict change in confrontation naming accuracy of untrained words post-treatment from ASPL. Several post-hoc analyses were also conducted.

Outcomes and results

We found no effect of ASPL on change in confrontation naming accuracy of untrained words immediately post- and 3-months post-treatment. However, post-hoc analyses indicated significant subject heterogeneity and limitations in observable path distance between trained and untrained words.

Conclusion

Despite the clinical trial report that confrontation naming of untrained words improved after PMT, we found no overall effect of ASPL on the amount of improvement. We discuss further investigation of the entire domain of phonological sequence knowledge (the phonological sequence knowledge landscape) and its influence on treatment generalization, and the potential importance of identifying predictors of treatment response to enhance the effects of treatment generalization.

中文翻译：

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在失语症的语音治疗中实现更大泛化的挑战

摘要

背景

刺激选择对失范症治疗很重要，因为心理词典中受过训练和未受过训练的词之间的相似性可能会影响治疗的泛化。我们专注于语音运动治疗 (PMT) 临床试验中受过训练和未受过训练的单词之间的语音相似性，该试验表明未经训练的单词在治疗后的对抗命名准确性方面有所提高。捕获训练词和未训练词之间相似度的一种方法是考虑词之间的语音网络路径距离。我们假设语音网络中受过训练和未受过训练的单词之间的距离可以解释处理后对抗命名准确性的提高。

目的

定义受过训练和未受过训练的单词之间影响对抗命名准确性后处理变化的语音网络距离。

方法和程序

我们回顾性分析了 28 名接受 PMT 作为临床试验一部分的失语症患者的数据。参与者完成了与治疗刺激的语音距离不同的单词的对抗命名（基线、治疗后和治疗后 3 个月）。我们使用语音网络来计算平均最短路径长度 (ASPL)，由未训练单词和所有训练单词之间的音素差异数定义。我们使用混合效应回归模型来预测来自 ASPL 的未经训练的单词后处理的对抗命名准确性的变化。还进行了几项事后分析。

结果和结果

我们发现 ASPL 对治疗后立即和治疗后 3 个月的未训练单词的对抗命名准确性变化没有影响。然而，事后分析表明受训词和未受训词之间的可观察路径距离存在显着的主题异质性和局限性。

结论

尽管临床试验报告称 PMT 后未经训练的单词的对抗命名有所改善，但我们发现 ASPL 对改善量没有总体影响。我们讨论了对整个语音序列知识领域（语音序列知识景观）及其对治疗泛化的影响的进一步调查，以及识别治疗反应预测因子以增强治疗泛化效果的潜在重要性。