Abstract

Two new phenanthrenes, Hemecitones A and B, were isolated from Hemerocallis fulva (L.) L. Their structures were determined by UV, IR, HR-ESI-MS, 1D and 2D NMR analysis. The in vitro cytotoxic activities of compounds 1 and 2 were studied against breast carcinoma MDA-MB-231, hepatocellular carcinoma HepG2 and lung carcinoma A549 cell lines. And compounds 1 and 2 exhibited anti-proliferative effects against these least one of the three types of cell lines with IC₅₀ ranging from 12.57 ± 2.34 to 31.22 ± 1.36 μM.

中文翻译：

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Hemecitones A 和 B：来自 Hemerocallis fulva (L.) L 的两种具有细胞毒性的菲

摘要

从Hemerocallis fulva (L.) L中分离出两种新的菲，Hemecitones A 和 B。它们的结构通过 UV、IR、HR-ESI-MS、1D 和 2D NMR 分析确定。研究了化合物1和2对乳腺癌 MDA-MB-231、肝细胞癌 HepG2 和肺癌 A549 细胞系的体外细胞毒活性。化合物1和2对这三种细胞系中的至少一种具有抗增殖作用，IC ₅₀范围为 12.57 ± 2.34 至 31.22 ± 1.36 μM。