Peptide-based hydrogels as delivery systems for doxorubicin,Journal of Peptide Science

当前位置： X-MOL 学术 › J. Pept. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Peptide-based hydrogels as delivery systems for doxorubicin
Journal of Peptide Science ( IF 1.8 ) Pub Date : 2021-01-24 , DOI: 10.1002/psc.3301
Carlo Diaferia ₁ , Elisabetta Rosa ₁ , Antonella Accardo ₁ , Giancarlo Morelli ₁

Affiliation

Hydrogels (HGs) and nanogels (NGs) have been recently identified as innovative supramolecular materials for many applications in biomedical field such as in tissue engineering, optoelectronic, and local delivery of active pharmaceutical ingredients (APIs). Due to their in vivo biocompatibility, synthetic accessibility, low cost, and tunability, peptides have been used as suitable building blocks for preparation of HGs and NGs formulations. Peptide HGs have shown an outstanding potential to deliver small drugs, protein therapeutics, or diagnostic probes, maintaining the efficacy of their loaded molecules, preventing degradation phenomena, and responding to external physicochemical stimuli. In this review, we discuss the possible use of peptide-based HGs and NGs as vehicles for the delivery of the anticancer drug doxorubicin (Dox). This anthracycline is clinically used for leukemia, stomach, lung, ovarian, breast, and bladder cancer therapy. The loading of Dox into supramolecular systems (liposomes, micelles, hydrogels, and nanogels) allows reducing its cardiotoxicity. According to a primary sequence classification of the constituent peptide, doxorubicin-loaded systems are here classified in short and ultra-short peptide-based HGs, RGD, or RADA-peptide-based HGs and peptide-based NGs.

中文翻译：

基于肽的水凝胶作为多柔比星的递送系统

水凝胶 (HG) 和纳米凝胶 (NG) 最近已被确定为创新的超分子材料，可用于生物医学领域的许多应用，例如组织工程、光电和活性药物成分 (API) 的局部递送。由于它们的体内生物相容性、合成可及性、低成本和可调节性，肽已被用作制备 HG 和 NG 制剂的合适构件。肽 HG 在递送小药物、蛋白质治疗剂或诊断探针、保持其负载分子的功效、防止降解现象以及对外部物理化学刺激作出反应方面已显示出显着的潜力。在这篇综述中，我们讨论了基于肽的 HG 和 NG 作为递送抗癌药物阿霉素 (Dox) 的载体的可能用途。这种蒽环类药物在临床上用于白血病、胃癌、肺癌、卵巢癌、乳腺癌和膀胱癌的治疗。将 Dox 加载到超分子系统（脂质体、胶束、水凝胶和纳米凝胶）中可以降低其心脏毒性。根据组成肽的一级序列分类，负载阿霉素的系统在这里分为基于短肽和超短肽的 HG、RGD 或基于 RADA 肽的 HG 和基于肽的 NG。

更新日期：2021-01-24

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11