Comparative hematopoiesis and signal transduction in model organisms,Journal of Cellular Physiology

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Comparative hematopoiesis and signal transduction in model organisms
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2021-01-25 , DOI: 10.1002/jcp.30287
Dushyant Kumar Gautam ₁ , Anuradha Venkatakrishnan Chimata ₂ , Ravi Kumar Gutti ₁ , Indira Paddibhatla ₁

Affiliation

Hematopoiesis is a continuous phenomenon involving the formation of hematopoietic stem cells (HSCs) giving rise to diverse functional blood cells. This developmental process of hematopoiesis is evolutionarily conserved, yet comparably different in various model organisms. Vertebrate HSCs give rise to all types of mature cells of both the myeloid and the lymphoid lineages sequentially colonizing in different anatomical tissues. Signal transduction in HSCs facilitates their potency and specifies branching of lineages. Understanding the hematopoietic signaling pathways is crucial to gain insights into their deregulation in several blood‐related disorders. The focus of the review is on hematopoiesis corresponding to different model organisms and pivotal role of indispensable hematopoietic pathways. We summarize and discuss the fundamentals of blood formation in both invertebrate and vertebrates, examining the requirement of key signaling nexus in hematopoiesis. Knowledge obtained from such comparative studies associated with developmental dynamics of hematopoiesis is beneficial to explore the therapeutic options for hematopoietic diseases.

中文翻译：

模式生物的比较造血和信号转导

造血是一种持续的现象，涉及造血干细胞 (HSC) 的形成，从而产生多种功能性血细胞。这种造血发育过程在进化上是保守的，但在各种模式生物中却大不相同。脊椎动物 HSC 产生了髓系和淋巴系的所有类型的成熟细胞，这些细胞依次定植在不同的解剖组织中。HSC 中的信号转导促进了它们的效力并指定了谱系的分支。了解造血信号通路对于深入了解它们在几种血液相关疾病中的失调至关重要。审查的重点是与不同模式生物相对应的造血和不可或缺的造血途径的关键作用。我们总结并讨论了无脊椎动物和脊椎动物血液形成的基本原理，研究了造血过程中关键信号连接的要求。从这些与造血发育动力学相关的比较研究中获得的知识有利于探索造血疾病的治疗选择。

更新日期：2021-01-25

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