Photothermal therapy (PTT) has presented its inherent application value in cancer treatment. Nevertheless, single-functional photothermal materials cannot meet the precise diagnosis and treatment of cancer. Therefore, it is important to design a nanocomposite that has both high therapeutic efficiency and multimodal imaging capabilities. In our work, a new nanostructure of gold nanorods (AuNRs) with silver shells decorated by BaGdF₅:Yb³⁺,Er³⁺ nanoparticle was synthesized by a simple way. The biostability of AuNRs is increased by coating with silver shells, and the AuNR@Ag nanoparticles can be used as excellent surface enhanced Raman scattering (SERS) probe. Moreover, the modification of BaGdF₅:Yb³⁺,Er³⁺ nanoparticles provides the possibility of real-time optical imaging of the tumor area. Under the irradiation of NIR laser, the AuNR@Ag/BaGdF₅:Yb³⁺,Er³⁺ nanocomposites (NCs) have strong upconversion emission and excellent photothermal conversion efficiency. Meanwhile, the NCs show low cytotoxicity and good biocompatibility in MTT cytotoxicity test. Moreover, the NCs are also exceptional contrast agents for CT imaging. For in vitro photothermal therapy test, NCs show excellent killing efficiency on tumor cells. Therefore, the multifaceted research of AuNR@Ag/BaGdF₅:Yb³⁺,Er³⁺ multifunctional nanomaterials provides a break for high-efficiency tumor photothermal therapy and multimodal imaging.

光热疗法（PTT）在癌症治疗中呈现出其固有的应用价值。然而，单一功能的光热材料无法满足癌症的精准诊断和治疗。因此，设计一种同时具有高治疗效率和多模态成像能力的纳米复合材料非常重要。在我们的工作中，通过简单的方法合成了一种由BaGdF ₅ :Yb ³⁺ ,Er ^{3+纳米粒子修饰的银壳金纳米棒（AuNRs）的新纳米结构。}AuNRs 的生物稳定性通过镀银壳提高，AuNR@Ag 纳米粒子可用作优异的表面增强拉曼散射 (SERS) 探针。此外，BaGdF ₅ :Yb ³⁺ ,Er³⁺纳米粒子提供了对肿瘤区域进行实时光学成像的可能性。在近红外激光照射下，AuNR@Ag/BaGdF ₅ :Yb ³⁺ ,Er ³⁺纳米复合材料（NCs）具有很强的上转换发射和优异的光热转换效率。同时，NCs在MTT细胞毒性试验中表现出较低的细胞毒性和良好的生物相容性。此外，NC 还是 CT 成像的特殊造影剂。对于体外 光热疗法测试，NCs对肿瘤细胞表现出优异的杀伤效率。因此，AuNR@Ag/BaGdF ₅ :Yb ³⁺ ,Er ^{3+的多方面研究} 多功能纳米材料为高效肿瘤光热治疗和多模态成像提供了突破口。