Here we demonstrate that binuclear dinitrosyl iron complexes with thiol-containing ligands (glutathione and mercaptosuccinate, B-DNIC-GSH and B-DNIC-MS, respectively) exert cytotoxic effects on MCF7 human breast cancer cells. We showed that they are mediated by nitrosonium cations released from these complexes (NO⁺). This finding is supported by the cytotoxic effect of both B-DNICs on MCF7 cells evidenced to retain or was even promoted in the presence of N-Methyl-D-glucamine dithiocarbamate (MGD). MGD recruits an iron nitrosyl group [Fe(NO)] from the iron-dinitrosyl fragment [Fe(NO)₂] of B-DNIC-MS forming stable mononitrosyl complexes of iron with MGD and releasing NO⁺ cations from a [Fe(NO)₂] fragment.

在这里，我们证明双核二亚硝基铁配合物与含硫醇的配体（分别为谷胱甘肽和巯基琥珀酸酯，B-DNIC-GSH和B-DNIC-MS）对MCF7人乳腺癌细胞发挥细胞毒性作用。我们证明了它们是由这些络合物（NO ⁺）释放的硝化阳离子所介导的。两种B-DNIC对MCF7细胞的细胞毒性作用都支持了这一发现，在N-甲基-D-葡糖胺二硫代氨基甲酸酯（MG​​D）的存在下，MCF7细胞被保留或什至被促进。MGD从B-DNIC-MS的铁-二亚硝酰基片段[Fe（NO）₂ ]募集亚硝基铁[Fe（NO）]，形成稳定的铁与MGD的单亚硝酰基络合物，并从[Fe（NO）释放NO ⁺阳离子）₂ ]片段。