The past decades have seen a growing interest in natural products. Caffeic acid phenethyl ester (CAPE), a flavonoid isolated from honeybee propolis, has shown multiple pharmacological potentials, including anti-cancer, anti-inflammatory, antioxidant, antibacterial, antifungal, and protective effects on nervous systems and multiple organs, since it was found as a potent nuclear factor κB (NF-κB) inhibitor. This review summarizes the advances in these beneficial effects of CAPE, as well as the underlying mechanisms, and proposes that CAPE offers an opportunity for developing therapeutics in multiple diseases. However, clinical trials on CAPE are necessary and encouraged to obtain certain clinically relevant conclusions.

在过去的几十年里，人们对天然产品的兴趣与日俱增。咖啡酸苯乙酯 (CAPE) 是一种从蜂胶中分离出来的黄酮类化合物，自被发现以来已显示出多种药理潜力，包括抗癌、抗炎、抗氧化、抗菌、抗真菌以及对神经系统和多个器官的保护作用作为一种有效的核因子 κB (NF-κB) 抑制剂。这篇综述总结了 CAPE 的这些有益作用的进展以及潜在机制，并提出 CAPE 为开发多种疾病的治疗方法提供了机会。然而，CAPE 的临床试验是必要的，并鼓励获得某些临床相关的结论。