The purpose of this study is to demonstrate the synthesis of pyrazole-based ligands and to evaluate their catalytic properties in the oxidation reaction of catechol to o-quinone. The ligands were prepared via the condensation of (3,5-dimethyl-1H pyrazol-1-yl)methanol A with the appropriate primary amine. Four pyrazole-based ligands were successfully synthesized and characterized. These ligands provide one pyrazole sp²-nitrogen, one pyridine sp²-nitrogen, and one amine sp³-nitrogen, which were capable of coordinating to the metal. For evaluating the catalytic activity, the experiments were tested by varying the type of solvent, metal ion, anion in the metal salt, and ratios of ligands and metal salts. Excellent catalytic activities for the oxidation of catechol to o-quinone were obtained. The copper (II)-based complexes showed better reactions rates than those based on other metals (e.g., nickel, tin, and barium), which was due to the fact that the active catalytic site of the catecholase enzyme has two active sites from the existence of copper (II) ions. The composition ratios of ligands and metal salts as well as the type of anion in the metal salt bring impacts to the formation of complexes. We found also that the type of solvent contributes to the interaction and dilution of reactants in the solvent. This study demonstrated that the present ligands can be used as a model for further developments in catalytic processes relating to catecholase activity.

这项研究的目的是证明吡唑基配体的合成，并评估其在邻苯二酚氧化为邻醌的氧化反应中的催化性能。通过（3，5-二甲基-1H吡唑-1-基）甲醇A与适当的伯胺的缩合制备配体。成功地合成和表征了四种吡唑基配体。这些配体提供一种吡唑sp ^2-氮，一种吡啶sp ^2-氮和一种胺sp ³-氮，能够与金属配位。为了评估催化活性，通过改变溶剂的类型，金属离子，金属盐中的阴离子以及配体和金属盐的比例来测试实验。获得了优异的催化活性，将邻苯二酚氧化为邻醌。基于铜（II）的配合物显示出比基于其他金属（例如镍，锡和钡）的反应更快的反应速率，这是由于以下事实：儿茶酚酶的活性催化位点有两个铜离子的存在。配体和金属盐的组成比以及金属盐中阴离子的类型对络合物的形成产生影响。我们还发现，溶剂的类型有助于溶剂中反应物的相互作用和稀释。