Foodborne bacterial pathogens in consumed foods are major food safety concerns worldwide, leading to serious illness and even death. An exciting strategy is to use novel phenolic compounds against bacterial pathogens based on recruiting the inducible metabolic responses of plant endogenous protective defense against biotic and abiotic stresses. Such stress-inducible phenolic metabolites have high potential to reduce bacterial contamination, and particularly improve safety of plant foods. The stimulation of plant protective response by inducing biosynthesis of stress-inducible phenolics with antimicrobial properties is among the safe and effective strategies that can be targeted for plant food safety and human gut health benefits. Metabolically driven elicitation with physical, chemical, and microbial elicitors has shown significant improvement in the biosynthesis of phenolic metabolites with antimicrobial properties in food and medicinal plants. Using the above rationale, this review focuses on current advances and relevance of metabolically driven elicitation strategies to enhance antimicrobial phenolics in plant food models for bacterial-linked food safety applications. Additionally, the specific objective of this review is to explore the potential role of redox-linked pentose phosphate pathway (PPP) regulation for enhancing biosynthesis of stress-inducible antibacterial phenolics in elicited plants, which are relevant for wider food safety and human health benefits.

中文翻译：

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诱导应激诱导的酚类代谢物用于对抗食源性人类细菌病原体的抗菌应用


食用食品中的食源性细菌病原体是全世界主要的食品安全问题，可导致严重疾病甚至死亡。一个令人兴奋的策略是使用新型酚类化合物来对抗细菌病原体，其基础是招募植物内源性保护防御的诱导代谢反应来对抗生物和非生物胁迫。这种应激诱导的酚类代谢物具有减少细菌污染的巨大潜力，特别是提高植物性食品的安全性。通过诱导具有抗菌特性的应激诱导酚类生物合成来刺激植物保护反应是安全有效的策略之一，可以针对植物食品安全和人类肠道健康益处。物理、化学和微生物诱导子的代谢驱动诱导已显示出食品和药用植物中具有抗菌特性的酚类代谢物的生物合成显着改善。基于上述基本原理，本综述重点关注代谢驱动的诱导策略的当前进展和相关性，以增强植物性食品模型中抗菌酚类物质的作用，以实现与细菌相关的食品安全应用。此外，本次综述的具体目标是探索氧化还原连接的磷酸戊糖途径（PPP）调节在增强诱导植物中应激诱导的抗菌酚类生物合成方面的潜在作用，这与更广泛的食品安全和人类健康益处相关。