Chiral Pd-Catalyzed Enantioselective Syntheses of Various N–C Axially Chiral Compounds and Their Synthetic Applications,Accounts of Chemical Research

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Chiral Pd-Catalyzed Enantioselective Syntheses of Various N–C Axially Chiral Compounds and Their Synthetic Applications
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2021-01-22 , DOI: 10.1021/acs.accounts.0c00767
Osamu Kitagawa ₁

Affiliation

Biaryl atropisomers are key structural components in chiral ligands, chiral functional materials, natural products, and bioactive compounds, and their asymmetric syntheses have been reported by many groups. In contrast, although the scientific community has long been aware of atropisomers due to rotational restriction around N–C bonds, they have attracted scant attention and have remained an unexplored research area. In particular, their catalytic asymmetric synthesis and the synthetic applications were unknown until recently. This Account describes studies conducted by our group on the catalytic enantioselective syntheses of N–C axially chiral compounds and their applications in asymmetric reactions.

中文翻译：

各种NC轴向手性化合物的手性Pd催化对映选择性合成及其应用

联芳基阻转异构体是手性配体，手性功能材料，天然产物和生物活性化合物中的关键结构组分，许多团体已经报道了它们的不对称合成。相比之下，尽管科学界早就意识到由于N-C键周围的旋转限制而引起的阻转异构体，但它们引起的关注很少，并且仍是一个尚未探索的研究领域。特别地，直到最近才知道它们的催化不对称合成和合成应用。该报告描述了我们小组对NC轴向手性化合物的催化对映选择性合成及其在不对称反应中的应用的研究。

更新日期：2021-02-02

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