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Recent Developments in Remote Meta‐C−H Bond Functionalizations
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-01-22 , DOI: 10.1002/adsc.202001053
Rashid Ali 1 , RAFIA SIDDIQUI 1
Affiliation  

In the past decades, there has been a dramatic increase in the developments of novel methods for the activation/functionalization of inert C−H bonds as these protocols are not only competent, reduce the waste materials in addition to the reaction time and multiple steps but also allows the reaction to be carried out in a highly regio‐specific manner under operationally simple yet effective reaction conditions. Although, in recent years, a remarkable progress has been made in the field of ortho‐and para‐C−H bonds functionalization but to our best knowledge, the distal meta‐C−H activation/functionalization is still infancy and is yet to be explore to the advanced level. Hence, we feel that there is an urgent need to aware the research community about where the field of meta‐C−H functionalization stand at present and where it might be going in near future. To this context, we strive to compile the significant achievements made in the selective meta‐C−H bonds functionalization since 2018 to till date. More interestingly, we have also displayed an overview of the earlier reports related to the meta‐C−H activation/functionalization at the beginning of this particular manuscript, and hopefully the present review article will open diverse opportunities for the advancement of both academia as well as industry.

中文翻译:

远程Meta-C-H键功能化的最新发展

在过去的几十年中,用于惰性CH键的活化/功能化的新方法的开发有了显着的增长,因为这些方案不仅有效,而且还减少了反应时间和多个步骤,还减少了废物。还可以在操作简单但有效的反应条件下以高度区域特异性的方式进行反应。虽然,近年来,一个显着的进步已经在该领域取得-和-C-H键功能化,但据我们所知,远端‐C-H激活/功能化仍处于起步阶段,尚待进一步研究。因此,我们感到迫切需要让研究人员了解meta -C-H功能化领域目前的位置以及在不久的将来可能会发生的情况。在此背景下,我们努力汇编自2018年至今迄今在选择性meta -C-H键功能化方面取得的重大成就。更有趣的是,我们还在此特殊手稿的开头显示了与meta -C-H激活/功能化相关的早期报告的概述,希望本综述文章也将为学术界的发展打开各种机遇。作为行业。
更新日期:2021-03-03
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