Efficient and Clean Nickel Catalyzed α‐Allylation Reaction of Nitriles,Advanced Synthesis & Catalysis

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Efficient and Clean Nickel Catalyzed α‐Allylation Reaction of Nitriles
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-01-22 , DOI: 10.1002/adsc.202001338
Bouchaib Mouhsine ₁ , Abdallah Karim ₂ , Clément Dumont ₃ , Isabelle Suisse ₁ , Mathieu Sauthier ₄

Affiliation

A clean method has been developed for the α‐allylation of phenyl and alpha alkyl phenyl acetonitrile with allylic alcohols. The reaction is catalyzed by nickel complexes in situ generated from a combination of Ni(cod)₂ and the dppf ligand and performed at 80 °C in methanol as reaction solvent. Accordingly to this simple and base‐free protocol that only yields water as a side‐product, many allylic nitriles were synthetized with good yields.

中文翻译：

高效，清洁的镍催化腈的α-烯丙基化反应

已开发出一种清洁的方法，用于将苯基和α-烷基苯基乙腈与烯丙基醇进行α-烯丙基化。该反应由Ni（cod）₂和dppf配体的组合生成的镍配合物催化，并在80°C的甲醇中作为反应溶剂进行。由于这种简单且无碱的方案仅产生水作为副产物，因此合成了许多烯丙基腈，收率很高。

更新日期：2021-03-03

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