Recent Progress in Palladium‐Catalyzed Radical Reactions,Advanced Synthesis & Catalysis

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Recent Progress in Palladium‐Catalyzed Radical Reactions
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-01-22 , DOI: 10.1002/adsc.202001315
Xi Sun ₁ , Xu Dong ₁ , Hui Liu ₂ , Yuying Liu ₃

Affiliation

In recent years, great improvements have been made on palladium‐catalyzed radical reactions. Emerging elegant methodologies of radical involved palladium‐catalyzed transformations provide more and more effective strategies for the construction of complex heterocyclic compounds and applications in drug discovery. It is universally known that Pd(0)/(II)/(IV)‐mediated reactions usually undergo two‐electron transfer processes, while the Pd(I) and Pd(III) involved reactions usually occur via single electron transfer processes. Since our review on palladium radical was published, numurous methodolgies involving palladium radical have sprung up in the past five years. This review further summarized the up‐to‐date transformations toward palladium radical from 2015. For most of these catalytic cycles strategies, plausible mechanisms are demonstrated in detail to give better insight for chemists in need.

中文翻译：

钯催化自由基反应的最新进展

近年来，钯催化的自由基反应已取得了很大的进步。自由基修饰钯催化转化的新兴优雅方法论为复杂杂环化合物的构建及其在药物发现中的应用提供了越来越有效的策略。众所周知，Pd（0）/（II）/（IV）介导的反应通常经历两电子转移过程，而Pd（I）和Pd（III）参与的反应通常通过单电子转移过程。自我们发表有关钯基的评论以来，在过去五年中涌现了许多涉及钯基的方法。这篇综述进一步总结了从2015年起向钯自由基的最新转变。对于大多数这些催化循环策略，详细论证了合理的机制，以便为有需要的化学家提供更好的见识。

更新日期：2021-03-16

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