Removal of new antiviral drug sofosbuvir from aqueous solution by non-modified expanded perlite (E-perlite) using adsorption process was investigated. Perlite is high-grade stone rich on silica utilized as inexpensive natural adsorbent. An experimental combination of Response Surface Methodology (RSM) with Central Composite Design (CCD) was applied to optimize the process parameters effecting the adsorption efficiency where the three used major independent variables are pH, adsorbent mass, and initial concentration of sofosbuvir. The results showed that maximum adsorption was attained at solution pH 6.8, sofosbuvir initial concentration 0.1 mM and E-perlite mass 20 g/L. Adsorption data were exploited by applying the kinetic models pseudo first-order, pseudo second-order, and intra-particle diffusion. The adsorption process corresponded to the Langmuir model while the adsorption kinetics correlated appropriately to the pseudo second-order equation. The morphology and composition of E-perlite were characterized by scanning electron microscopy (SEM/EDS).

研究了使用吸附工艺通过未改性的膨胀珍珠岩（E-珍珠岩）从水溶液中去除新的抗病毒药物索非布韦。珍珠岩是富含二氧化硅的高级石材，可用作廉价的天然吸附剂。应用响应表面方法学（RSM）和中央复合设计（CCD）的实验组合来优化影响吸附效率的工艺参数，其中使用的三个主要独立变量是pH，吸附剂质量和sofosbuvir的初始浓度。结果表明，在溶液pH 6.8，sofosbuvir初始浓度0.1 mM和E-珍珠岩质量20 g / L时达到最大吸附。通过应用动力学模型伪一阶，伪二阶和粒子内扩散来利用吸附数据。吸附过程与Langmuir模型相对应，而吸附动力学与伪二级方程相关。通过扫描电子显微镜（SEM / EDS）表征了E-珍珠岩的形貌和组成。