Biapenem is parenteral carbapenem antibiotic with a broad spectrum of activity. The objective of the study was to confirm that β-radiation irradiation with electron beam with a delivered dose of 25 kGy allows to obtain a sterile biapen, characterized by unchanged physicochemical and microbiological properties. Biological and chemical changes of biapenem were only observed when 400 kGy was used (the dose 16 times higher than dose needed to sterilization). The degradation product from radiolysis was identified by the LC-MS/MS method. Radiosterilization Radiation sterilization is safe and effective method of biapenem sterilization.

中文翻译：

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放射灭菌是获得无菌比阿培南的安全有效方法

比阿培南是具有广泛活性的肠胃外碳青霉烯类抗生素。该研究的目的是确认β-辐射用电子束以25 kGy的剂量辐照可以得到无菌的biapen，其特征是物理化学和微生物特性保持不变。仅在使用400 kGy时才观察到比阿培南的生物学和化学变化（该剂量比灭菌所需剂量高16倍）。通过LC-MS / MS方法鉴定了辐射分解产生的降解产物。放射消毒 放射灭菌是比阿培南灭菌的安全有效方法。