This research, for the first time, report the synthesis of core-shell magnetic nanoparticles (NPs) consisting poly acrylic acid (PAA) coated cobalt ferrite (CF) using a simple co-precipitation route. Nanocrystalline PAA@CF-NPs, particle size of 9.4 nm, exhibited saturation magnetization as 28.9 emu/g, remnant magnetization as 8.37 emu/g, and coercivity as 543 Oe. Keeping biomedical applications into consideration, PAA@CF-NPs were further analysed to evaluate antimicrobial performance against Gram positive (Staphylococcus aureus and Bacillus subtilis) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacteria, and biocompatibility with reference to activated splenic cells. The PAA@CF-NPs were viable to the normal splenic cells (up to 1000 μg/ml) and do not affect the ability of fast dividing ability of the cells (activated splenic cells). An optimized dose of PAA@CF-NPs was intramuscularly administrated (100 μg/ml) into Albino mice to evaluate acute toxicity. The results of these studies suggest that injected PAA@CF-NPs do not affect vital organs mainly including liver and kidneys that confirmed the heptic/renal biocompatibility. The outcomes of this research project such developed nano-system for biomedical applications, mainly for magnetically guided drug delivery and image guided therapies development. However, to support the proposed claims, extended in-vivo studies are required to explore bio-distribution, chronic toxicity, and homeostatic conditions.

这项研究首次报道了使用简单的共沉淀途径合成由聚丙烯酸（PAA）涂层的钴铁氧体（CF）组成的核-壳磁性纳米颗粒（NPs）。纳米晶体PAA @ CF-NPs，粒径为9.4 nm，饱和磁化强度为28.9 emu / g，残余磁化强度为8.37 emu / g，矫顽力为543 Oe。考虑到生物医学应用，进一步分析了PAA @ CF-NPs，以评估其对革兰氏阳性（金黄色葡萄球菌和枯草芽孢杆菌）和革兰氏阴性（铜绿假单胞菌和大肠杆菌）的抗菌性能。）细菌和生物相容性（相对于活化的脾细胞）。PAA @ CF-NP对正常的脾脏细胞（高达1000μg/ ml）具有活力，并且不影响细胞（活化的脾脏细胞）的快速分裂能力。将最佳剂量的PAA @ CF-NPs肌肉注射（100μg/ ml）注入白化病小鼠以评估急性毒性。这些研究的结果表明，注射的PAA @ CF-NPs不会影响主要器官，包括肝脏和肾脏，这些器官证实了人类与肾脏的生物相容性。这项研究项目的成果是，开发出了用于生物医学应用的纳米系统，主要用于磁引导药物输送和图像引导疗法的开发。但是，为支持所提出的权利要求，需要进行扩展的体内研究以探讨生物分布，慢性毒性，