The present investigation is the first report containing design and synthesis of novel calixarene derivatives (6–8) and their inclusion complexes (IC6–IC8) with Chloramphenicol (CAM). After synthesis, the antibiotic CAM, calixarene derivatives (6–8) and their inclusion complexes (IC6–IC8) were successfully incorporated into biodegradable PVA and/or PLA nanofiber skeleton by electrospinning. The obtained electrospun nanofibers were tested and compared for inhibition of bacterial growth towards multiple bacterial species (Escherichia coli, and Bacillus subtilis). Moreover, we evaluated thermal decomposition and release profile of CAM by spectrophotometric methods. The results suggested that CAM can be successfully encapsulated in nanofiber webs by inclusion complexation, and these fibers could be used as a part of new controlled release packaging system for food preservation.

本研究是含有新型杯芳烃衍生物（的设计和合成的第一次报告6 - 8）和它们的包合配合物（IC6 - IC8）与氯霉素（CAM）。合成，抗生素CAM，杯芳烃衍生物（后6 - 8以及它们的包合配合物（）IC6 - IC8）通过电成功掺入生物可降解的PVA和/或纳米纤维的PLA骨架。测试获得的电纺纳米纤维，并比较其对多种细菌（大肠杆菌）细菌生长的抑制作用和枯草芽孢杆菌）。此外，我们通过分光光度法评估了CAM的热分解和释放曲线。结果表明，可以通过包合复合物成功地将CAM包裹在纳米纤维网中，并且这些纤维可以用作食品保鲜的新型控释包装系统的一部分。