Immunological memory is a mechanism to protect us against reinfection. Antibodies produced by B cells are integral to this defense strategy and underlie virtually all vaccine success. Here, we explain how B cells memory is generated by infection and vaccination, what influences its efficacy and its persistence, and how characterizing these parameters in the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will help achieve protective immunity through vaccination.

中文翻译：

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B 细胞记忆：了解 COVID-19

免疫记忆是一种保护我们免受再次感染的机制。B 细胞产生的抗体是这种防御策略不可或缺的一部分，几乎是所有疫苗成功的基础。在这里，我们解释了 B 细胞记忆是如何通过感染和疫苗接种产生的，是什么影响了它的功效和持久性，以及在对严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 的免疫反应中表征这些参数将如何帮助实现保护性通过接种疫苗获得免疫力。