In the present study, a sustainable and efficient deep eutectic solvent (DES)-based ultrasound-assisted extraction method for Sapodilla pulp polyphenols was developed. Seven different DESs prepared using carboxylic acid, polyol and amide were evaluated and compared with an aqueous-organic solvent mixture- acetone–water (50%)- the control used in this study. Low pH and high polarity markedly enhanced the recovery of the polyphenols in acid-based DESs. The highest yield was obtained with oxaline, followed by maloline and laline, as the presence of three OH groups considerably retarded the interaction between DES and target compounds, enhanced the viscosity and reduced the availability of H-bonding sites in glyceline and maline. Although the extraction rate was considerably slower in highly viscous DESs, the time required to attain the equilibrium was only marginally higher for oxaline and maloline than the acetone–water mixture. Reduced air incorporation due to high viscosity and strong H-bonding with DESs also substantially enhanced the storage stability of released antioxidants in DES. The low pH of carboxylic acid constituents and innate toxicity of urea at high concentration were responsible for high antimicrobial activity of acid, and amide-based DES extracts against Aspergillus and Bacillus. However, cell lysis and enzyme inhibitory properties of polyphenols were responsible for antimicrobial activities of polyol-based DESs and organic solvent-based extracts. However, the ability of fungi to metabolize the substrates effectively reduced DESs’ efficiency against the organism compared to bacteria. Therefore, these solvents have great potential as possible alternatives to conventional solvents health-related areas, such as food and medicines.

在本研究中，一种可持续，有效的基于深共晶（DES）的超声波辅助提取人心果的方法开发了纸浆多酚。对使用羧酸，多元醇和酰胺制备的7种不同的DES进行了评估，并与本研究中使用的水-有机溶剂混合物（丙酮-水（50％））进行了比较。低pH和高极性显着提高了酸基DES中多酚的回收率。用草胺，然后用苹果酸和脯氨酸获得最高的收率，因为三个OH基团的存在大大阻碍了DES和目标化合物之间的相互作用，增加了粘度，并降低了在甘氨酸和苹果酸中的H键位。尽管在高粘度的DES中萃取速度要慢得多，但是草酸和苹果酸达到平衡所需的时间仅比丙酮-水混合物略高。由于高粘度和与DES的强H键结合而减少的空气掺入也大大增强了DES中释放的抗氧化剂的储存稳定性。羧酸成分的低pH值和高浓度尿素的先天毒性导致了酸的高抗菌活性，酰胺基DES提取物对曲霉和芽孢杆菌。然而，多酚的细胞裂解和酶抑制特性决定了多元醇基DES和有机溶剂基提取物的抗菌活性。但是，与细菌相比，真菌代谢底物的能力有效降低了DES对抗生物体的效率。因此，这些溶剂具有巨大的潜力，可以替代食品和药品等与健康相关的传统领域。