Landslide-induced tsunamis may cause fatalities, damages and financial losses. In the Three Gorges Reservoir Area of China, several large landslides are still unstable and persistently creeping toward the Yangtze River. In this paper, we investigate the impacts of landslide-induced tsunamis in the Three Gorges Reservoir by using a hybrid numerical approach. One of the largest unstable mass in this area, the Huangtupo landslide, is chosen as the study object. First, the landslide deformation and initiating velocities are obtained by using the finite-discrete element method. The landslide-induced tsunamis and their impacts on shipping on the Yangtze River are then investigated through smooth particle hydrodynamics modelling. Our results reveal that an approximately 80% reduction in shear strength of the tip in the landslide will lead to catastrophic failure of the landslide, with sliding velocities of up to 8 m/s. Subsequently, such a collapse may initiate a river tsunami, propagating up to 9 m on the nearby reservoir banks within 3 km. The impacts on surrounding floating objects, such as surges and sways, heaves and rolls, are up to 110 m, 8 m and 6°, respectively. The simulations indicate that although the likelihood of a catastrophic failure of the whole landslide is low, the partial sliding still poses severe threat to the nearby reservoir banks and shipping on the Yangtze River. Thus, we recommend continuous monitoring as well as landslide early warning systems at this and also other hazardous sites in this area.