Membranous nephropathy is an autoimmune disease caused by antibodies mostly directed to podocyte antigens. PLA2R and THSD7A antigens were described in 2009 and 2014 using classical immunochemical techniques. In the last 2 years, thanks to the combination of laser microdissection of glomeruli and mass spectrometry of solubilized digested proteins, several antigens associated with various causes have been described in patients with membranous nephropathy. The purpose of this review is to report on those "new" antigens and to analyse the clinicopathological correlations that make each of this antigen unique.

中文翻译：

---

膜性肾病：根据新靶抗原对各种病因的当前了解。

膜性肾病是一种主要由针对足细胞抗原的抗体引起的自身免疫性疾病。PLA2R 和 THSD7A 抗原于 2009 年和 2014 年使用经典免疫化学技术进行了描述。在过去的两年中，由于肾小球激光显微切割和溶解消化蛋白的质谱分析相结合，在膜性肾病患者中描述了与各种原因相关的几种抗原。本综述的目的是报告这些“新”抗原并分析使每种抗原独特的临床病理学相关性。