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Transition-metal-free decarboxylative thiolation of stable aliphatic carboxylates
RSC Advances ( IF 3.9 ) Pub Date : 2021-1-22 , DOI: 10.1039/d1ra00063b Wei-Long Xing 1 , De-Guang Liu 1 , Ming-Chen Fu 1
RSC Advances ( IF 3.9 ) Pub Date : 2021-1-22 , DOI: 10.1039/d1ra00063b Wei-Long Xing 1 , De-Guang Liu 1 , Ming-Chen Fu 1
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A transition-metal-free decarboxylative thiolation protocol is reported in which primary, secondary, tertiary (hetero)aryl acetates and α-CN substituted acetates undergo the decarboxylative thiolation smoothly, to deliver a variety of functionalized aryl alkyl sulfides in moderate to excellent yields. Aryl diselenides are also amenable substrates for construction of C–Se bonds under the simple and mild reaction conditions. Moreover, the protocol is successfully applied to the late-stage modification of pharmaceutical carboxylates with satisfactory chemoselectivity and functional-group compatibility.
中文翻译：
稳定脂肪族羧酸盐的无过渡金属脱羧硫醇化
报道了一种无过渡金属的脱羧硫醇化方案，其中伯、仲、叔（杂）芳基乙酸酯和α-CN 取代的乙酸酯顺利地进行脱羧硫醇化，以中等至优异的产率提供各种功能化的芳基烷基硫化物。芳基二硒化物也是在简单温和的反应条件下构建 C-Se 键的合适底物。此外，该方案成功应用于药物羧酸盐的后期修饰，具有令人满意的化学选择性和官能团相容性。
更新日期：2021-01-22
中文翻译：
稳定脂肪族羧酸盐的无过渡金属脱羧硫醇化
报道了一种无过渡金属的脱羧硫醇化方案，其中伯、仲、叔（杂）芳基乙酸酯和α-CN 取代的乙酸酯顺利地进行脱羧硫醇化，以中等至优异的产率提供各种功能化的芳基烷基硫化物。芳基二硒化物也是在简单温和的反应条件下构建 C-Se 键的合适底物。此外，该方案成功应用于药物羧酸盐的后期修饰，具有令人满意的化学选择性和官能团相容性。
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