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Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications
Nanoscale ( IF 5.8 ) Pub Date : 2021-1-7 , DOI: 10.1039/d0nr08478f Huizhen Zheng 1, 2, 3, 4, 5 , Jun Jiang 1, 2, 3, 4, 5 , Shujuan Xu 1, 2, 3, 4, 5 , Wei Liu 6, 7, 8, 9, 10 , Qianqian Xie 1, 2, 3, 4, 5 , Xiaoming Cai 4, 5, 10, 11, 12 , Jie Zhang 10, 13, 14, 15 , Sijin Liu 6, 7, 8, 9, 10 , Ruibin Li 1, 2, 3, 4, 5
Nanoscale ( IF 5.8 ) Pub Date : 2021-1-7 , DOI: 10.1039/d0nr08478f Huizhen Zheng 1, 2, 3, 4, 5 , Jun Jiang 1, 2, 3, 4, 5 , Shujuan Xu 1, 2, 3, 4, 5 , Wei Liu 6, 7, 8, 9, 10 , Qianqian Xie 1, 2, 3, 4, 5 , Xiaoming Cai 4, 5, 10, 11, 12 , Jie Zhang 10, 13, 14, 15 , Sijin Liu 6, 7, 8, 9, 10 , Ruibin Li 1, 2, 3, 4, 5
Affiliation
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Although ferroptosis is an iron-dependent cell death mechanism involved in the development of some severe diseases (e.g., Parkinsonian syndrome, stroke and tumours), the combination of nanotechnology with ferroptosis for the treatment of these diseases has attracted substantial research interest. However, it is challenging to differentiate nanoparticle-induced ferroptosis from other types of cell deaths (e.g., apoptosis, pyroptosis, and necrosis), elucidate the detailed mechanisms and identify the key property of nanoparticles responsible for ferroptotic cell deaths. Therefore, a summary of these aspects from current research on nano-ferroptosis is important and timely. In this review, we endeavour to summarize some convincing techniques that can be employed to specifically examine ferroptotic cell deaths. Then, we discuss the molecular initiating events of nanosized ferroptosis inducers and the cascade signals in cells, and therefore elaborate the ferroptosis mechanisms. Besides, the key physicochemical properties of nano-inducers are also discussed to acquire a fundamental understanding of nano-structure–activity relationships (nano-SARs) involved in ferroptosis, which may facilitate the design of nanomaterials to deliberately tune ferroptosis. Finally, future perspectives on the fundamental understanding of nanoparticle-induced ferroptosis and its applications are provided.
中文翻译：
纳米颗粒引起的肥大病：检测方法，机理和应用
尽管肥大症是与某些严重疾病（例如帕金森综合症，中风和肿瘤）有关的铁依赖性细胞死亡机制，但是纳米技术与肥大症相结合的治疗这些疾病已引起了广泛的研究兴趣。然而，将纳米颗粒诱导的肥大病与其他类型的细胞死亡（例如，凋亡，凋亡和坏死）阐明了详细的机制，并确定了导致肥大细胞死亡的纳米颗粒的关键特性。因此，从当前对纳米铁肥大病的研究中总结这些方面是重要且及时的。在这篇综述中，我们努力总结一些令人信服的技术，这些技术可用于专门检查肥大细胞死亡。然后，我们讨论了纳米铁肥大症诱导剂的分子引发事件和细胞中的级联信号，从而阐述了铁肥大症的发病机理。此外，还讨论了纳米诱导物的关键理化特性，以获取对与肥大化有关的纳米结构-活性关系（nano-SARs）的基本了解，这可能有助于设计纳米材料来故意调整肥大化。
更新日期：2021-01-22
中文翻译：
纳米颗粒引起的肥大病：检测方法，机理和应用
尽管肥大症是与某些严重疾病（例如帕金森综合症，中风和肿瘤）有关的铁依赖性细胞死亡机制，但是纳米技术与肥大症相结合的治疗这些疾病已引起了广泛的研究兴趣。然而，将纳米颗粒诱导的肥大病与其他类型的细胞死亡（例如，凋亡，凋亡和坏死）阐明了详细的机制，并确定了导致肥大细胞死亡的纳米颗粒的关键特性。因此，从当前对纳米铁肥大病的研究中总结这些方面是重要且及时的。在这篇综述中，我们努力总结一些令人信服的技术，这些技术可用于专门检查肥大细胞死亡。然后，我们讨论了纳米铁肥大症诱导剂的分子引发事件和细胞中的级联信号，从而阐述了铁肥大症的发病机理。此外，还讨论了纳米诱导物的关键理化特性，以获取对与肥大化有关的纳米结构-活性关系（nano-SARs）的基本了解，这可能有助于设计纳米材料来故意调整肥大化。
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