当前位置: X-MOL 学术J. Ophthal. Inflamm. Infect. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Intravenous administration of Penicillin results in therapeutic intravitreal levels in chronic postoperative endophthalmitis
Journal of Ophthalmic Inflammation and Infection ( IF 2.9 ) Pub Date : 2021-01-22 , DOI: 10.1186/s12348-020-00232-0
Chloe Thabet 1 , Chloe C C Gottlieb 1, 2, 3 , Bernard R Hurley 1, 2, 3 , Guijun Zhang 3 , Adeel Sherazi 4 , Jonathan B Angel 1, 3, 4
Affiliation  

The role of systemic antibiotics in the treatment of bacterial endophthalmitis remains controversial. While penicillin is a highly effective antibiotic against bacteria that frequently cause endophthalmitis, the ability of systemically administered Penicillin G to penetrate into the vitreous at adequate therapeutic concentrations has not been studied. Its role in the treatment of endophthalmitis, particularly for bacteria for which it is the antibiotic of choice, therefore remains unknown. We sought to determine whether intravenous administration of Penicillin G leads to adequate therapeutic concentrations in the vitreous for the treatment of bacterial endophthalmitis. This study was conducted in an ambulatory setting, at the Ottawa Hospital Eye Institute, a university-affiliated tertiary care center, where a 77-year old gentleman with chronic post-cataract surgery Actinomyces neuii endophathalmitis was treated with intravenous Penicillin G (4 × 106 units every 4 h) and intravitreal ampicillin (5000μg/0.1 m1). Intravitreal concentration of Penicillin G and ampicillin were obtained at the time of intraocular lens removal, measured by high-performance liquid chromatography. The intravitreal concentration of penicillin and ampicillin was 3.5μg/ml and 0.3μg/ml, respectively. Both the concentration of penicillin and ampicillin were within the level of detection of their respective assays (penicillin 0.06-5μg/ml, ampicillin 0.12–2.5μg/ml). This study shows that intravenous Penicillin G administered every four-hours allows for adequate intravitreal concentrations of penicillin. Future studies are required to determine if the results of this study translate into improved clinical outcomes.

中文翻译:


静脉注射青霉素可达到治疗慢性术后眼内炎的玻璃体内水平



全身抗生素在治疗细菌性眼内炎中的作用仍存在争议。虽然青霉素是一种针对经常引起眼内炎的细菌的高效抗生素,但系统施用青霉素 G 以足够的治疗浓度渗透到玻璃体的能力尚未得到研究。因此,它在治疗眼内炎中的作用,特别是对于选择它作为抗生素的细菌的作用,仍然未知。我们试图确定静脉注射青霉素 G 是否会在玻璃体中产生足够的治疗浓度来治疗细菌性眼内炎。这项研究是在渥太华医院眼科研究所(大学附属三级护理中心)的门诊环境中进行的,一位患有慢性白内障手术后放线菌内炎的 77 岁绅士接受静脉注射青霉素 G(4 × 106每 4 小时一次)和玻璃体内注射氨苄青霉素(5000μg/0.1 m1)。摘除人工晶状体时,通过高效液相色谱法测量青霉素 G 和氨苄青霉素的玻璃体内浓度。青霉素和氨苄青霉素的玻璃体内浓度分别为3.5μg/ml和0.3μg/ml。青霉素和氨苄青霉素的浓度均在各自测定的检测水平内(青霉素0.06-5μg/ml,氨苄青霉素0.12-2.5μg/ml)。这项研究表明,每四小时静脉注射一次青霉素 G 可以保证玻璃体内有足够的青霉素浓度。未来的研究需要确定这项研究的结果是否可以转化为改善的临床结果。
更新日期:2021-01-22
down
wechat
bug