Cancer-related fatigue has been related to circadian disruptions and lower levels of sleep quality. However, it is unknown whether the circadian phase, which is associated with chronotype and timing of sleep, is related to fatigue after cancer. The aims of this study were to investigate the associations between (1) chronotype and cancer-related fatigue and (2) sleep quality and cancer-related fatigue. In this cross-sectional questionnaire study, 458 (non-)Hodgkin lymphoma survivors (n = 231 female, mean age 49.7 years) completed a Visual Analogue Scale for fatigue (VAS-fatigue) from 0 (no fatigue) to 10 (worst imaginable fatigue), the Munich Chronotype Questionnaire (MCTQ), and the Pittsburgh Sleep Quality Index (PSQI) between October 2018 and July 2019. A hierarchical linear regression analysis was used to evaluate the associations between the dependent variable fatigue and chronotype (based on early, intermediate, or late average midsleep) in Model 1, and fatigue and sleep quality in Model 2. The results showed no indications for an association between chronotype and fatigue (all p values ≥ 0.50). There were associations between two (out of seven) aspects of sleep quality and fatigue: subjective sleep quality (p < 0.001) and daily dysfunctioning (p < 0.001). Therefore, it is more likely that fatigue is associated with self-reported sleep quality rather than with chronotype. However, experimental studies with objective, physiological data on circadian phase and sleep quality are necessary to confirm the conclusions of this cross-sectional study.

与癌症相关的疲劳与昼夜节律紊乱和睡眠质量低下有关。然而，与睡眠时间类型和时间相关的昼夜节律阶段是否与癌症后的疲劳有关尚不清楚。本研究的目的是调查 (1) 睡眠类型与癌症相关疲劳和 (2) 睡眠质量与癌症相关疲劳之间的关联。在这项横断面问卷调查中，458 名（非）霍奇金淋巴瘤幸存者（n = 231 名女性，平均年龄 49.7 岁）完成了从 0（无疲劳）到 10（可想象的最差）的疲劳视觉模拟量表（VAS-疲劳）疲劳)、2018 年 10 月至 2019 年 7 月期间的慕尼黑睡眠类型问卷 (MCTQ) 和匹兹堡睡眠质量指数 (PSQI)。使用分层线性回归分析来评估因变量疲劳与睡眠类型（基于早期、中期，或平均睡眠中后期），模型 2 中的疲劳和睡眠质量。结果显示没有迹象表明睡眠类型和疲劳之间存在关联（所有p值 ≥ 0.50）。睡眠质量和疲劳的两个（共七个）方面之间存在关联：主观睡眠质量 ( p < 0.001) 和日常功能障碍 ( p< 0.001)。因此，疲劳更有可能与自我报告的睡眠质量有关，而不是与睡眠类型有关。然而，需要对昼夜节律阶段和睡眠质量的客观生理数据进行实验研究，以确认这项横断面研究的结论。