Aging is strongly correlated with several noncommunicable disorders such as diabetes, obesity, cardiovascular disease, and neurodegenerative conditions. Glucosamine (2-amino-2-deoxy-d-glucose, GlcN) is a naturally occurring amino sugar and is reported to act as a caloric restriction mimetic (CRM). In young and d-galactose-induced accelerated rat aging models, we tested a persistent oral dietary dose of GlcN and evaluated various aging biomarkers in erythrocytes and plasma. A significant increase in the reactive oxygen species (ROS) was observed in GlcN-treated young and accelerated senescent rat model. Increased value of ferric reducing ability of plasma (FRAP), superoxide dismutase, catalase, and plasma membrane redox system (PMRS) was observed. We suggest that GlcN induces a mitohormetic impact by a transient increase in ROS. Our findings indicate that GlcN may be a successful CRM.

中文翻译：

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葡萄糖胺通过激活 Mitohormosis 在衰老大鼠中显示出有效的热量限制模拟作用

衰老与多种非传染性疾病密切相关，例如糖尿病、肥胖症、心血管疾病和神经退行性疾病。葡糖胺（2-氨基-2-脱氧d葡萄糖，葡萄糖胺）是一种天然存在的氨基酸和糖被报告给充当热量限制模拟物（CRM）。在年轻和d-半乳糖诱导的大鼠加速衰老模型，我们测试了持续口服膳食剂量的 GlcN 并评估了红细胞和血浆中的各种衰老生物标志物。在 GlcN 处理的年轻和加速衰老大鼠模型中观察到活性氧 (ROS) 显着增加。观察到血浆 (FRAP)、超氧化物歧化酶、过氧化氢酶和质膜氧化还原系统 (PMRS) 的铁还原能力值增加。我们建议 GlcN 通过 ROS 的瞬时增加诱导有丝分裂影响。我们的发现表明 GlcN 可能是一个成功的 CRM。