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Antiproliferative Bufadienolides from the Bulbs of Drimia altissima
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-01-21 , DOI: 10.1021/acs.jnatprod.0c01079 Linda Langat 1 , Moses K Langat 1, 2 , Wolfgang Wetschnig 3 , Walter Knirsch 3 , Dulcie A Mulholland 1, 2
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-01-21 , DOI: 10.1021/acs.jnatprod.0c01079 Linda Langat 1 , Moses K Langat 1, 2 , Wolfgang Wetschnig 3 , Walter Knirsch 3 , Dulcie A Mulholland 1, 2
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The bulbs of the South African Drimia altissima (Asparagaceae or Hyacinthaceae sensu APGII) have yielded a range of previously undescribed bufadienolides, drimianins A–G (1–7), the known bufadienolides bovogenin A (8), 3β-O-β-d-glucopyranosylbovogenin A (9), scillaren F (10), and altoside (11), the known homoisoflavonoid (3S)-3-(4′-methoxybenzyl)-5,6,7-trimethoxychroman-4-one (urgineanin C), the sesquiterpenoids 1β,6α-dihydroxy-4(15)-eudesmene and 6α-hydroxy-4(15)-eudesmen-1-one, polybotrin, adenosine, and 9R-hydroxy-(10E,12Z)-octadecadienoic acid ethyl ester. The bufadienolides isolated were tested at 10 μM in the NCI-60 cancer cell screen, and nine of these were selected for further screening at five concentrations. Drimianins C (3) and E (5) showed activity at the nanomolar level against a number of human cancer cell lines in the NCI-60 screen.
中文翻译：
来自 Drimia altissima 球茎的抗增殖 Bufadienolides
南非的灯泡判官笔属臭椿（天门冬科或风信子意义上APGII）已经产生了一系列以前未描述bufadienolides的，drimianins A-G（1 - 7），已知的bufadienolides bovogenin A（8），3β- O- β- d -吡喃葡萄糖基Bovogenin A ( 9 )、scillaren F ( 10 ) 和 altoside ( 11 )，已知的同型异黄酮 (3 S ) - 3-(4'-甲氧基苄基)-5,6,7-trimethoxychroman-4-one (urgineanin C )、倍半萜类化合物 1β,6α-dihydroxy-4(15)-eudesmene 和 6α-hydroxy-4(15)-eudesmen-1-one、polybotrin、腺苷和 9 R-羟基-(10 E ,12 Z )-十八碳二烯酸乙酯。在 NCI-60 癌细胞筛选中以 10 μM 对分离的蟾蜍二烯内酯进行了测试，并选择了其中的九个以五种浓度进行进一步筛选。Drimianins C ( 3 ) 和 E ( 5 ) 在 NCI-60 筛选中显示出针对多种人类癌细胞系的纳摩尔水平的活性。
更新日期：2021-03-26
中文翻译：
来自 Drimia altissima 球茎的抗增殖 Bufadienolides
南非的灯泡判官笔属臭椿（天门冬科或风信子意义上APGII）已经产生了一系列以前未描述bufadienolides的，drimianins A-G（1 - 7），已知的bufadienolides bovogenin A（8），3β- O- β- d -吡喃葡萄糖基Bovogenin A ( 9 )、scillaren F ( 10 ) 和 altoside ( 11 )，已知的同型异黄酮 (3 S ) - 3-(4'-甲氧基苄基)-5,6,7-trimethoxychroman-4-one (urgineanin C )、倍半萜类化合物 1β,6α-dihydroxy-4(15)-eudesmene 和 6α-hydroxy-4(15)-eudesmen-1-one、polybotrin、腺苷和 9 R-羟基-(10 E ,12 Z )-十八碳二烯酸乙酯。在 NCI-60 癌细胞筛选中以 10 μM 对分离的蟾蜍二烯内酯进行了测试，并选择了其中的九个以五种浓度进行进一步筛选。Drimianins C ( 3 ) 和 E ( 5 ) 在 NCI-60 筛选中显示出针对多种人类癌细胞系的纳摩尔水平的活性。
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