Engineering a Smart Nanofluidic Sensor for High-Performance Peroxynitrite Sensing through a Spirocyclic Ring Open/Close Reaction Strategy,ACS Sensors

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Engineering a Smart Nanofluidic Sensor for High-Performance Peroxynitrite Sensing through a Spirocyclic Ring Open/Close Reaction Strategy
ACS Sensors ( IF 8.2 ) Pub Date : 2021-01-22 , DOI: 10.1021/acssensors.0c01719
Yangyan Li ₁ , Le Tu _{2,

3} , Xin Ma ₃ , Huan Chen ₄ , Yifan Fan ₅ , Qiang Zhou ₁ , Yao Sun ₃

Affiliation

Peroxynitrite (ONOO^–) is an important reactive oxygen/nitrogen species that participates in a range of physiological and pathological processes by modulating ion flux through biological channels. Inspired by a ONOO^–-regulated K⁺ channel in vivo, herein, we describe the construction of a smart ONOO^–-driven nanosensor using a spirocyclic ring open/close reaction approach. The prepared nanosensor possessed a prominent ONOO^– selectivity and sensitivity and rapid response (∼90 s) owing to the specific reaction between ONOO^– and ligands on the nanosensor surface with a high ion rectification ratio (∼10) and ion gating ratio (∼4). Moreover, this nanosensor system also exhibits excellent stability and recyclability. Thus, these results will provide a new direction for the design of nanochannel-based sensors for future practical and biological applications.

中文翻译：

通过螺环开/闭反应策略设计用于高性能过氧亚硝酸盐传感的智能纳米流体传感器

过氧亚硝酸盐（ONOO ^–）是重要的活性氧/氮物质，通过调节通过生物通道的离子通量来参与各种生理和病理过程。由ONOO启发^-调控的ķ ⁺体内通道，在此，我们描述了一种智能ONOO的建设^-使用螺环打开/关闭反应的方法驱动的纳米传感器。制备的纳米传感器具有显着的ONOO ^–选择性和灵敏度，并且由于ONOO ^–之间的特定反应而具有快速响应（〜90 s）^。纳米传感器表面上的配体具有高的离子整流比（〜10）和离子门控比（〜4）。而且，该纳米传感器系统还表现出优异的稳定性和可回收性。因此，这些结果将为未来的实际和生物学应用中基于纳米通道的传感器的设计提供新的方向。

更新日期：2021-03-26

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