The COVID-19 pandemic caused by the new coronavirus (SARS-CoV-2) has become a global emergency issue for public health. This threat has led to an acceleration in related research and, consequently, an unprecedented volume of clinical and experimental data that include changes in gene expression resulting from infection. The SARS-CoV-2 infection database (SARSCOVIDB: https://sarscovidb.org/) was created to mitigate the difficulties related to this scenario. The SARSCOVIDB is an online platform that aims to integrate all differential gene expression data, at messenger RNA and protein levels, helping to speed up analysis and research on the molecular impact of COVID-19. The database can be searched from different experimental perspectives and presents all related information from published data, such as viral strains, hosts, methodological approaches (proteomics or transcriptomics), genes/proteins, and samples (clinical or experimental). All information was taken from 24 articles related to analyses of differential gene expression out of 5,554 COVID-19/SARS-CoV-2-related articles published so far. The database features 12,535 genes whose expression has been identified as altered due to SARS-CoV-2 infection. Thus, the SARSCOVIDB is a new resource to support the health workers and the scientific community in understanding the pathogenesis and molecular impact caused by SARS-CoV-2.

中文翻译：

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SARSCOVIDB——分析 SARS-CoV-2 病毒感染分子影响的新平台

由新型冠状病毒（SARS-CoV-2）引起的COVID-19大流行已成为全球公共卫生的紧急问题。这种威胁导致了相关研究的加速，从而产生了前所未有的大量临床和实验数据，其中包括感染引起的基因表达的变化。创建 SARS-CoV-2 感染数据库（SARSCOVIDB：https://sarscovidb.org/）是为了缓解与这种情况相关的困难。SARSCOVIDB 是一个在线平台，旨在整合信使 RNA 和蛋白质水平上的所有差异基因表达数据，有助于加快对 COVID-19 分子影响的分析和研究。该数据库可以从不同的实验角度进行搜索，并提供已发表数据的所有相关信息，例如病毒株、宿主、方法学途径（蛋白质组学或转录组学）、基因/蛋白质和样本（临床或实验）。所有信息均取自迄今为止发表的 5,554 篇 COVID-19/SARS-CoV-2 相关文章中的 24 篇与差异基因表达分析相关的文章。该数据库包含 12,535 个基因，这些基因的表达已被确定因 SARS-CoV-2 感染而发生改变。因此，SARSCOVIDB 是支持卫生工作者和科学界了解 SARS-CoV-2 的发病机制和分子影响的新资源。