Prompt and reliable diagnosis of invasive pulmonary aspergillosis (IPA) is essential for early initiation of antifungal therapy. We evaluated bronchoalveolar lavage (BAL) fluid IMMY Sona Aspergillus lateral-flow assay (IMMY LFA) in 92 individuals with suspected pulmonary infection. Sensitivity and specificity (vs. host factor but no IPA) of BAL IMMY LFA for diagnosis of IPA in individuals with any European Organisation for Research and Treatment of Cancer-defied “host factor” were 67% and 85%, respectively. Performance appeared better in individuals with renal transplantation (100%, 100%), compared to those with hematological malignancy and/or allogenic stem cell transplantation (70%, 78%). We found BAL IMMY LFA to be a convenient and useful addition to our diagnostic armory for IPA.

中文翻译：

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支气管肺泡灌洗液 IMMY Sona Aspergillus 侧向流检测用于诊断侵袭性肺曲霉病：一项前瞻性的现实生活评估

侵袭性肺曲霉病 (IPA) 的及时和可靠诊断对于早期开始抗真菌治疗至关重要。我们评估了 92 名疑似肺部感染患者的支气管肺泡灌洗液 (BAL) IMMY Sona Aspergillus侧向流检测 (IMMY LFA)。BAL IMMY LFA 在任何欧洲癌症研究和治疗组织定义的“宿主因子”中诊断 IPA 的敏感性和特异性（与宿主因子相比，但没有 IPA）分别为 67% 和 85%。与血液系统恶性肿瘤和/或同种异体干细胞移植患者（70%、78%）相比，肾移植患者的表现更好（100%、100%）。我们发现 BAL IMMY LFA 是我们 IPA 诊断库的方便且有用的补充。