Non-communicable chronic diseases (NCDs) are nowadays the principal cause of death, especially in most industrialized nations. These illnesses have increased exponentially with the consumption of diets very high in fat and sugar, not to mention stress and physical inactivity among other factors. The potential impact of suboptimal diets on NCDs’ morbidity and mortality rates brings to the forefront the necessity for a new way of improving dietary habits. The literature provides extensive scientific work that presents evidence that phenolic compounds from diets have antioxidant, anti-inflammatory and antiproliferative activities that impact human health. Gut microbiota modulation by some phenolic compounds leads to favorable changes in abundance, diversity, and in the immune system. However, polyphenol’s limited bioavailability needs to be overcome, highlighting their application in new delivery systems and providing their health benefits in well-established ways such as health maintenance, treatment or adjuvant to conventional pharmacological treatments. In this context, novel dietary approaches, including new food supplements, have emerged to prevent diseases and preserve health.

中文翻译：

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酚类化合物对类风湿关节炎，炎性肠病和微生物群调节的影响

如今，非传染性慢性病（NCD）是主要的死亡原因，尤其是在大多数工业化国家中。这些疾病随着饮食中脂肪和糖分的大量摄入而成倍增加，更不用说压力和缺乏身体活动等因素。最不理想的饮食对非传染性疾病发病率和死亡率的潜在影响使人们有必要提出一种改善饮食习惯的新方法。文献提供了广泛的科学成果，这些证据表明饮食中的酚类化合物具有抗氧化，抗炎和抗增殖的活性，会影响人体健康。某些酚类化合物对肠道菌群的调节作用会导致丰度，多样性和免疫系统发生有利变化。但是，需要克服多酚有限的生物利用度，重点介绍它们在新的给药系统中的应用，并以完善的方式（如健康维护，治疗或常规药理治疗的辅助剂）提供健康益处。在这种情况下，出现了新的饮食方法，包括新的食品补充剂，以预防疾病和保持健康。