The prevalence of sarcopenia, frailty and fractures is increasing. Prevention options are limited, but dietary factors including vitamin E have the potential to confer some protection. This study investigated cross-sectional associations between dietary and plasma concentrations of vitamin E with indices of skeletal muscle mass (SMM) (n = 14,179 and 4283, respectively) and bone density (n = 14,694 and 4457, respectively) and longitudinal fracture risk (n = 25,223 and 7291, respectively) in European Prospective Investigation Into Cancer and Nutrition (EPIC)-Norfolk participants, aged 39–79 years at baseline. Participants completed a health and lifestyle questionnaire, a 7-day diet diary (7dDD) and had anthropometric measurements taken. Fat-free mass (as a SMM proxy) was measured using bioimpedance and bone density was measured using calcaneal broadband ultrasound attenuation (BUA) and incident fractures over 18.5 years of follow-up. Associations between indices of SMM, BUA and fracture risk were investigated by quintiles of dietary vitamin E intake or plasma concentrations. Positive trends in SMM indices and BUA were apparent across dietary quintiles for both sexes, with interquintile differences of 0.88%–1.91% (p < 0.001), and protective trends for total and hip fracture risk. Circulating plasma α- and γ-tocopherol results matched the overall dietary findings. Dietary vitamin E may be important for musculoskeletal health but further investigation is required to fully understand the relationships of plasma tocopherols.

中文翻译：

---

EPIC-Norfolk 队列中维生素 E 的膳食摄入量和血浆浓度与骨骼肌质量、跟骨超声衰减和骨折风险的正相关

肌肉减少症、虚弱和骨折的患病率正在增加。预防选择有限，但包括维生素 E 在内的饮食因素有可能提供一些保护。本研究调查了维生素 E 的饮食和血浆浓度与骨骼肌质量 (SMM) 指数（分别为n = 14,179 和 4283）和骨密度指数（分别为n = 14,694 和 4457）和纵向骨折风险（n= 25,223 和 7291，分别）在欧洲癌症和营养前瞻性调查 (EPIC) - 诺福克参与者中，基线年龄为 39-79 岁。参与者完成了健康和生活方式调查问卷、7 天饮食日记 (7dDD) 并进行了人体测量。使用生物阻抗测量无脂肪质量（作为 SMM 代理），使用跟骨宽带超声衰减 (BUA) 和骨折事件测量骨密度超过 18.5 年的随访。通过膳食维生素 E 摄入量或血浆浓度的五分位数研究了 SMM、BUA 和骨折风险指数之间的关联。SMM 指数和 BUA 的积极趋势在两种性别的饮食五分位数中都很明显，五分位数之间的差异为 0.88%–1.91%（p< 0.001)，以及总体和髋部骨折风险的保护趋势。循环血浆 α- 和 γ- 生育酚结果与总体饮食结果相符。膳食维生素 E 可能对肌肉骨骼健康很重要，但需要进一步研究以充分了解血浆生育酚之间的关系。