Rhodomyrtone, a plant-derived principal compound isolated from Rhodomyrtus tomentosa (Myrtaceae) leaf extract, was assessed as a potential natural alternative for the treatment of acne vulgaris. The clinical efficacy of a 1% liposomal encapsulated rhodomyrtone serum was compared with a marketed 1% clindamycin gel. In a randomized and double-blind controlled clinical trial, 60 volunteers with mild to moderate acne severity were assigned to two groups: rhodomyrtone serum and clindamycin gel. The volunteers were instructed to apply the samples to acne lesions on their faces twice daily. A significant reduction in the total numbers of acne lesions was demonstrated in both treatment groups between weeks 2 and 8 (p < 0.05). Significant differences in acne numbers compared with the baseline were evidenced at week 2 onwards (p < 0.05). At the end of the clinical trial, the total inflamed acne counts in the 1% rhodomyrtone serum group were significantly reduced by 36.36%, comparable to 34.70% in the clindamycin-treated group (p < 0.05). Furthermore, a commercial prototype was developed, and a clinical assessment of 45 volunteers was performed. After application of the commercial prototype for 1 week, 68.89% and 28.89% of volunteers demonstrated complete and improved inflammatory acne, respectively. All of the subjects presented no signs of irritation or side effects during the treatment. Most of the volunteers (71.11%) indicated that they were very satisfied. Rhodomyrtone serum was demonstrated to be effective and safe for the treatment of inflammatory acne lesions.

中文翻译：

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Rhodomyrtone作为一种新的天然抗菌剂，从桃金娘（Rhodomyrtus tomentosa）叶提取物中分离：在寻常痤疮管理中的临床应用

Rhodomyrtone是一种植物来源的主要化合物，它是从桃金娘（Rhodomyrtus tomentosa）（桃金娘科）叶提取物中分离得到的，被认为是治疗寻常痤疮的潜在天然替代品。将1％脂质体包封的Rhodomyrtone血清的临床疗效与市售的1％克林霉素凝胶进行了比较。在一项随机，双盲对照的临床试验中，将60名轻度至中度痤疮严重程度的志愿者分为两组：罗丹明血清和克林霉素凝胶。指导志愿者每天两次将样品涂在脸上的痤疮病变上。两个治疗组在第2周和第8周之间痤疮病变总数显着减少（p<0.05）。从第2周开始，痤疮数量与基线相比有显着差异（p <0.05）。在临床试验结束时，罗丹明血清1％组的总炎症痤疮计数显着降低了36.36％，与克林霉素治疗组的34.70％相当（p<0.05）。此外，开发了商业原型，并对45名志愿者进行了临床评估。应用商业原型1周后，分别有68.89％和28.89％的志愿者表现出完全和改善的炎症性痤疮。所有受试者在治疗过程中均未出现刺激或副作用迹象。大多数志愿者（71.11％）表示非常满意。证明了紫丁香血清对于治疗炎性痤疮病变是有效和安全的。