This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated into four groups. Groups were then fed a nutritionally complete and balanced food with either 0, 75, 150 or 300 ppm of alpha-lipoic acid added for 6 months. Evaluations included physical examination, body weight, food intake, hematology, serum biochemistry profile and measurements of glutathione in plasma and erythrocyte lysates. Throughout, blood parameters remained within reference ranges, dogs were healthy and body weight did not change significantly. A significant increase of 0.05 ng/mL of total glutathione in red blood cell (RBC) lysate for each 1 mg/kg bodyweight/day increase in a-LA intake was observed. In addition, a significant increase was observed for GSH, GSSG and total glutathione in RBC lysate at Month 6. We conclude that alpha-lipoic acid, as part of a complete and balanced food, was associated with increasing glutathione activity in healthy adult dogs.

中文翻译：

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α-硫辛酸是健康成年犬的有效营养抗氧化剂


本研究旨在确定α-硫辛酸对健康成年犬谷胱甘肽状态的影响。在给狗喂食不含 α-硫辛酸的食物的 15 个月基线期后，狗被随机分为四组。然后给各组喂食营养全面且均衡的食物，添加 0、75、150 或 300 ppm 的 α-硫辛酸，持续 6 个月。评估包括体检、体重、食物摄入、血液学、血清生化特征以及血浆和红细胞裂解物中谷胱甘肽的测量。自始至终，血液参数都保持在参考范围内，狗很健康，体重没有明显变化。观察到，α-LA 摄入量每天每增加 1 mg/kg 体重，红细胞 (RBC) 裂解物中的总谷胱甘肽就会显着增加 0.05 ng/mL。此外，在第 6 个月时，红细胞裂解液中的 GSH、GSSG 和总谷胱甘肽显着增加。我们得出的结论是，α-硫辛酸作为完整均衡食物的一部分，与健康成年犬的谷胱甘肽活性增加有关。