Single-Molecule Förster Resonance Energy Transfer-Based Photosensitizer for Synergistic Photodynamic/Photothermal Therapy,ACS Central Science

当前位置： X-MOL 学术 › ACS Cent. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Single-Molecule Förster Resonance Energy Transfer-Based Photosensitizer for Synergistic Photodynamic/Photothermal Therapy
ACS Central Science ( IF 12.7 ) Pub Date : 2021-01-22 , DOI: 10.1021/acscentsci.0c01551
Yang Zou ₁ , Saran Long ₁ , Tao Xiong ₁ , Xueze Zhao ₁ , Wen Sun _{1,

2} , Jianjun Du _{1,

2} , Jiangli Fan _{1,

2} , Xiaojun Peng ₁

Affiliation

Photosensitizers (PSs) inevitably release a large amount of energy in the form of fluorescence during photodynamic therapy (PDT). However, under the premise of satisfying fluorescence imaging, a large amount of energy is lost, which limits the efficiency of tumor therapy. Accordingly, in this study, we developed a new strategy (BDP-CR) using the single-molecule Förster resonance energy transfer (smFRET) mechanism to transfer part of the fluorescent energy into heat for combined PDT and photothermal therapy (PTT) featuring the “1 + 1 > 2” amplification effect. Under the 671 nm light irradiation, BDP-CR can produce singlet oxygen (¹O₂) for PDT based on the BDP moiety and also generate hyperthermia to achieve the PTT effect by exciting CR based on the smFRET effect, which effectively kills cancer cells both in vitro and in vivo. This strategy exhibits a broad absorption peak with strong light-harvesting ability, which improves photon utilization for treatment while realizing fluorescence imaging. Of note, owing to the smFRET effect, we achieve a combination treatment outcome at relatively low concentrations and light doses. Thus, we believe that this design concept will provide a new strategy for single-molecule FRET photosensitizers in combination therapy of cancer with potential clinical application prospects.

中文翻译：

基于单分子福斯特共振能量转移的光敏剂，用于协同光动力/光热疗法

光敏剂（PSs）在光动力疗法（PDT）期间不可避免地会以荧光形式释放大量能量。然而，在满足荧光成像的前提下，大量的能量损失了，这限制了肿瘤治疗的效率。因此，在这项研究中，我们使用单分子Förster共振能量转移（smFRET）机制开发了一种新策略（BDP-CR），以将部分荧光能量转化为热量，从而将PDT与光热疗法（PTT）结合使用，其特点是“ 1 +1> 2英寸放大效果。在671 nm光照射下，BDP-CR可以在BDP的基础上为PDT产生单线态氧（¹ O ₂）部分和也产生热疗实现通过激励PTT效果CR基于所述smFRET效果，从而有效地杀死癌细胞两者在体外和体内。该策略具有宽吸收峰和强光捕获能力，可在实现荧光成像的同时提高光子的利用率。值得注意的是，由于smFRET效应，我们在相对较低的浓度和轻剂量下即可达到联合治疗的效果。因此，我们相信这种设计理念将为单分子FRET光敏剂在癌症的联合治疗中提供新的策略，具有潜在的临床应用前景。

更新日期：2021-02-24

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11