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Cupric Oxide Coating That Rapidly Reduces Infection by SARS-CoV-2 via Solids
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-01-22 , DOI: 10.1021/acsami.0c19465
Mohsen Hosseini 1 , Alex W H Chin 2 , Saeed Behzadinasab 1 , Leo L M Poon 2, 3 , William A Ducker 1
Affiliation  

The ongoing COVID-19 pandemic has created a need for coatings that reduce infection from SARS-CoV-2 via surfaces. Such a coating could be used on common touch surfaces (e.g., door handles and railings) to reduce both disease transmission and fear of touching objects. Herein, we describe the design, fabrication, and testing of a cupric oxide anti-SARS-CoV-2 coating. Rapid loss of infectivity is an important design criterion, so a porous hydrophilic coating was created to allow rapid infiltration of aqueous solutions into the coating where diffusion distances to the cupric oxide surface are short and the surface area is large. The coating was deposited onto glass from a dispersion of cuprous oxide in ethanol and then thermally treated at 700 °C for 2 h to produce a CuO coating that is ≈30 μm thick. The heat treatment oxidized the cuprous oxide to cupric oxide and sintered the particles into a robust film. The SARS-CoV-2 infectivity from the CuO film was reduced by 99.8% in 30 min and 99.9% in 1 h compared to that from glass. The coating remained hydrophilic for at least 5 months, and there was no significant change in the cross-hatch test of robustness after exposure to 70% ethanol or 3 wt % bleach.

中文翻译:

氧化铜涂层可通过固体快速减少 SARS-CoV-2 感染

持续不断的 COVID-19 大流行催生了对能够减少 SARS-CoV-2 通过表面感染的涂料的需求。这种涂层可用于常见的触摸表面(例如门把手和栏杆),以减少疾病传播和对触摸物体的恐惧。在此,我们描述了氧化铜抗 SARS-CoV-2 涂层的设计、制造和测试。感染性的快速丧失是一个重要的设计标准,因此创建了多孔亲水涂层,使水溶液能够快速渗透到涂层中,其中到氧化铜表面的扩散距离短且表面积大。该涂层由氧化亚铜在乙醇中的分散体沉积到玻璃上,然后在 700 °C 下热处理 2 小时,产生约 30 μm 厚的 CuO 涂层。热处理将氧化亚铜氧化成氧化铜,并将颗粒烧结成坚固的薄膜。与玻璃相比,CuO 薄膜的 SARS-CoV-2 感染性在 30 分钟内降低了 99.8%,在 1 小时内降低了 99.9%。涂层在至少5个月内保持亲水性,并且在暴露于70%乙醇或3重量%漂白剂后,在稳健性的划格法测试中没有显着变化。
更新日期:2021-02-10
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