ABSTRACT

We report here a facile, one-pot, environmentally friendly, and efficient protocol for the synthesis of quinoline derivatives from the condensation of 2-aminoarylketones and active methylene compounds catalyzed by inexpensive, nontoxic and environmentally benign FeCl₃.6H₂O catalyst. The results obtained by using FeCl₃.6H₂O catalyst were also compared with those described in the literature. This methodology offers several advantages such as shorter reaction time, milder conditions, easy workup, and better yields. The non-extractive workup/purification, economic and environmentally benign catalyst make this operationally straightforward procedure affordable for a large scale.

摘要

我们在这里报告了一种简便，一锅，环保且高效的方案，该方案可通过廉价，无毒且对环境无害的FeCl ₃ .6H ₂ O催化剂催化2-氨基芳基酮与活性亚甲基化合物的缩合反应合成喹啉衍生物。使用FeCl ₃ .6H ₂ O催化剂获得的结果也与文献中描述的结果进行了比较。该方法具有许多优点，例如反应时间短，条件温和，后处理容易和产率更高。非萃取性的后处理/纯化，经济和环境友好的催化剂使这种操作简单的方法可大规模地负担得起。