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Evaluation of Acute Reactions on Mouse Skin Irradiated with 222 and 235 nm UV-C
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2021-01-21 , DOI: 10.1111/php.13384
Nozomi Yamano 1 , Makoto Kunisada 1 , Aiko Nishiaki-Sawada 2 , Hiroyuki Ohashi 2 , Tatsushi Igarashi 2 , Chikako Nishigori 1
Affiliation  

Biological response and DNA damage following irradiation with shorter wavelengths in the UV-C range were evaluated to investigate the safety at three wavelengths because of the recent emergence of germicidal equipment emitting short-wavelength UV-C for various purposes, including medical uses. To estimate an acceptable safety dose for human skin in the UV-C range, especially short UV-C, we studied the biological effects of 207, 222 and 235 nm UV-C using albino hairless mice and evaluated the inflammatory reactions in the skin. To explore an appropriate indicator to evaluate the biological response, we employed determination of the minimal perceptible response dose (MPRD), by which any subtle cutaneous response; erythema, edema and scale could be observed by visual inspection. Erythema was rarely observed, but edema and scale formation were evident for short UV-C wavelengths. The MPRD at 207, 222 and 235 nm was determined to be > 15, 15 and 2.0 kJ m−2, respectively. These values could be thresholds and indicators for possible safety assessments. Our data suggest that the current human exposure limits for short UV-C wavelengths below 254 nm are overly restrictive and should be reconsidered for future disinfection lamps with short UV-C wavelengths.

中文翻译:

用 222 和 235 nm UV-C 照射小鼠皮肤的急性反应评估

由于最近出现了用于各种用途(包括医疗用途)的发射短波长 UV-C 的杀菌设备,因此评估了在 UV-C 范围内用较短波长照射后的生物反应和 DNA 损伤,以研究三种波长的安全性。为了估计人体皮肤在 UV-C 范围内的可接受安全剂量,尤其是短 UV-C,我们使用白化无毛小鼠研究了 207、222 和 235 nm UV-C 的生物学效应,并评估了皮肤的炎症反应。为了探索评估生物反应的适当指标,我们采用了最小可感知反应剂量(MPRD)的测定,通过该剂量可以发现任何细微的皮肤反应;肉眼可观察到红斑、水肿和鳞屑。很少观察到红斑,但对于短 UV-C 波长,水肿和水垢形成是明显的。在 207、222 和 235 nm 处的 MPRD 被确定为 > 15、15 和 2.0 kJ m-2,分别。这些值可能是可能的安全评估的阈值和指标。我们的数据表明,当前对低于 254 nm 的短 UV-C 波长的人体暴露限制过于严格,对于未来具有短 UV-C 波长的消毒灯应重新考虑。
更新日期:2021-01-21
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