Nonclassical antagonism between human lysozyme and AMPs against Pseudomonas aeruginosa,FEBS Open Bio

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Nonclassical antagonism between human lysozyme and AMPs against Pseudomonas aeruginosa
FEBS Open Bio ( IF 2.8 ) Pub Date : 2021-01-21 , DOI: 10.1002/2211-5463.13094
Ian Blumenthal ₁ , Lydia R Davis ₁ , Chet M Berman ₁ , Karl E Griswold _{1,

2}

Affiliation

Combinations of human lysozyme (hLYS) and antimicrobial peptides (AMPs) are known to exhibit either additive or synergistic activity, and as a result, they have therapeutic potential for persistent and antibiotic‐resistant infections. We examined hLYS activity against Pseudomonas aeruginosa when combined with six different AMPs. In contrast to prior reports, we discovered that some therapeutically relevant AMPs manifest striking antagonistic interactions with hLYS across particular concentration ranges. We further found that the synthetic AMP Tet009 can inhibit hLYS‐mediated bacterial lysis. To the best of our knowledge, these results represent the first observations of antagonism between hLYS and AMPs, and they advise that future development of lytic enzyme and AMP combination therapies considers the potential for antagonistic interactions.

中文翻译：

人溶菌酶与 AMP 对铜绿假单胞菌的非经典拮抗作用

已知人类溶菌酶 (hLYS) 和抗菌肽 (AMP) 的组合表现出加和或协同活性，因此，它们具有治疗持续性和抗生素耐药性感染的潜力。我们检查了 hLYS 对铜绿假单胞菌的活性与六种不同的 AMP 结合使用时。与之前的报告相反，我们发现一些治疗相关的 AMP 在特定浓度范围内与 hLYS 表现出惊人的拮抗相互作用。我们进一步发现合成的 AMP Tet009 可以抑制 hLYS 介导的细菌裂解。据我们所知，这些结果代表了对 hLYS 和 AMP 之间拮抗作用的首次观察，他们建议裂解酶和 AMP 联合疗法的未来发展考虑拮抗相互作用的潜力。

更新日期：2021-03-04

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