Although beta 2 adrenergic receptors (β₂ADR) are present in the keratinocytes, their role in cutaneous squamous cell tumorigenesis needs to be ascertained. For the first time, we report here that selective β₂ADR antagonists by inhibiting β₂ADR actions significantly retarded the progression of ultraviolet B (UVB) induced premalignant cutaneous squamous cell lesions. These antagonists acted by inhibiting vascular endothelial growth factor‐A (VEGF) mediated angiogenesis to prevent UVB radiation‐induced squamous cell carcinoma of the skin.

中文翻译：

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抑制 β2 肾上腺素能受体作用通过抑制 VEGF-A 诱导的血管生成来预防 UVB 介导的皮肤鳞状细胞肿瘤发生

尽管 β 2 肾上腺素能受体 (β ₂ ADR) 存在于角质形成细胞中，但它们在皮肤鳞状细胞肿瘤发生中的作用仍需确定。我们首次在此报道选择性β ₂ ADR 拮抗剂通过抑制β ₂ ADR 作用显着延缓了紫外线B (UVB) 诱导的癌前皮肤鳞状细胞病变的进展。这些拮抗剂通过抑制血管内皮生长因子-A (VEGF) 介导的血管生成来预防 UVB 辐射诱导的皮肤鳞状细胞癌。