Three titanium (Ti) compounds bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple-negative breast cancer (TNBC) MDA-MB-231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that (^HL^MeTi-O)₄ (IC₅₀ = 0.91 μM) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future.

中文翻译：

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含2,6-双（邻-羟烷基）吡啶配体的钛配合物对三阴性乳腺癌细胞的体外细胞毒性

合成了三种带有2,6-双（邻羟基烷基）吡啶配体的钛（Ti）化合物，并研究了其对三阴性乳腺癌（TNBC）MDA-MB-231细胞的体外细胞毒性。在体外对细胞TNBC复合物的细胞毒性的结果表明，（^ħ大号^我的Ti-O）₄（IC ₅₀ = 0.91  μ M）施加在TNBC细胞增殖的显著抑制作用。因此，将来作为非铂配合物的烷氧基钛配合物可用于结构优化，以治疗乳腺癌细胞。