Development and functionalization of DNA nanostructures for biomedical applications,Journal of the Chinese Chemical Society

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Development and functionalization of DNA nanostructures for biomedical applications
Journal of the Chinese Chemical Society ( IF 1.6 ) Pub Date : 2021-01-22 , DOI: 10.1002/jccs.202000373
Mirza Muhammad Faran Ashraf Baig ₁ , Ting Zou ₁ , Prasanna Neelakantan ₁ , Chengfei Zhang ₁

Affiliation

Nanomaterials are excellent drug delivery systems, yet, they must be functionalized in a manner compatible with the biological environment. Regarding delivery of the payloads, it is critical to monitor the nanocarrier's biocompatibility and the ability to control its drug encapsulation and release, as well as targeting. The current challenges include avoiding negative host immune responses, optimizing stability in biological environments, and achieving precise interactions with the targets. Contemporary advances in structural DNA nanotechnology, DNA origami, and supramolecular DNA assembly make it possible to produce complex multi‐functional DNA nanostructures, wherein precise control of the size, geometry, and appearance of the ligands is feasible. DNA nanostructures offer ease of synthesis and conjugation of functional moieties to target the release of cargo or to analyze important biomarkers for diagnostics. Furthermore, the biocompatibility, programmability, responsiveness to biomolecules, cell‐surfaces, and organisms make such DNA nanomaterials highly suitable for potential translational applications. This overview summarizes the recent developments in functionalizing, stabilizing, and applying DNA nanostructures for potential biomedical applications.

中文翻译：

生物医学应用DNA纳米结构的开发和功能化

纳米材料是出色的药物输送系统，但是，必须以与生物环境兼容的方式对其进行功能化。关于有效载荷的传递，至关重要的是监测纳米载体的生物相容性以及控制其药物封装和释放以及靶向的能力。当前的挑战包括避免负面的宿主免疫反应，优化生物环境的稳定性以及实现与靶标的精确相互作用。结构DNA纳米技术，DNA折纸和超分子DNA组装的当代进步使得生产复杂的多功能DNA纳米结构成为可能，其中精确控制配体的大小，几何形状和外观是可行的。DNA纳米结构可轻松合成和结合功能性部分，从而靶向释放货物或分析重要的生物标志物以进行诊断。此外，生物相容性，可编程性，对生物分子，细胞表面和生物的响应能力使此类DNA纳米材料非常适合潜在的翻译应用。此概述总结了功能化，稳定化和将DNA纳米结构用于潜在生物医学应用的最新进展。

更新日期：2021-02-24

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