At present, metabolic diseases, such as obesity and diabetes, have become the world's top health threats. These diseases are closely related to the abnormal development and function of adipocytes and metabolic inflammation associated with obesity. Histone deacetylase 11 (HDAC11), with a relatively unique structure and function in the HDAC family, plays a vital role in regulating cell growth, migration, and cell death. Currently, research on new key regulatory functions of HDAC11 in metabolic homeostasis is receiving more and more attention, and HDAC11 has also become a potential therapeutic target in the treatment of obesity and obesity‐related diseases. Here, we summarized the latest literature on the role of HDAC11 in regulating the progress of obesity‐related metabolic disorders.

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HDAC11 在肥胖相关代谢紊乱中的作用：批判性评论

目前，肥胖、糖尿病等代谢性疾病已成为全球最大的健康威胁。这些疾病与脂肪细胞的异常发育和功能以及与肥胖相关的代谢炎症密切相关。组蛋白去乙酰化酶 11 (HDAC11) 在 HDAC 家族中具有相对独特的结构和功能，在调节细胞生长、迁移和细胞死亡方面起着至关重要的作用。目前，HDAC11在代谢稳态中新的关键调控功能的研究越来越受到关注，HDAC11也成为治疗肥胖和肥胖相关疾病的潜在治疗靶点。在这里，我们总结了关于 HDAC11 在调节肥胖相关代谢紊乱进展中的作用的最新文献。