Buprenorphine is a partial opioid agonist commonly used to treat opioid dependence. The pharmacology of buprenorphine increases the risk of a precipitated opioid withdrawal when commencing patients on buprenorphine treatment, particularly when transferring from long acting opioids (e.g. methadone). There is little documented experience regarding the management of precipitated withdrawal. In our case, a patient developed a significant precipitated opioid withdrawal following buprenorphine administration, and was able to be successfully treated in hospital with further buprenorphine. This demonstrates that rapid increases in buprenorphine dose can be used as an effective treatment for buprenorphine‐induced precipitated opioid withdrawal. The use of buprenorphine to manage withdrawal then allows the individual to continue on this highly effective treatment.

中文翻译：

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用丁丙诺啡处理丁丙诺啡引起的阿片类药物戒断

丁丙诺啡是一种部分阿片类激动剂，常用于治疗阿片类药物依赖。当患者开始接受丁丙诺啡治疗时，丁丙诺啡的药理学会增加阿片类药物突然戒断的风险，尤其是从长效阿片类药物（例如美沙酮）转移时。关于突然戒断的管理，几乎没有记录在案的经验。在我们的案例中，一位患者在服用丁丙诺啡后出现了显着的阿片类药物戒断反应，并且能够在医院接受进一步的丁丙诺啡成功治疗。这表明快速增加丁丙诺啡剂量可作为丁丙诺啡诱发的阿片类药物戒断的有效治疗方法。